ArticleClinical rheumatology2019
Association between three non-insulin-based indexes of insulin resistance and hyperuricemia.
Article in Clinical rheumatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.
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Who cites it
35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- The association between the triglyceride-glucose index and serum uric acid: a systematic review and meta-analysis.BMC endocrine disorders · 2026Pooled it
- The Association Between the Triglyceride Glucose Index and Hyperuricemia: A Dose-Response Meta-Analysis.Nutrients · 2025Pooled it
- Pooled it
- The Predictive Value of Insulin Resistance Surrogates for Diabetic Kidney Disease in Type 2 Diabetes Mellitus.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2025Article
- Elevated uric acid level and metabolic syndrome in Non-Hispanic Black American adults.Journal of diabetes and metabolic disorders · 2025Article
- Comparisons of various insulin resistance indices for new-onset metabolic syndrome before midlife: The CHIEF cohort study, 2014-2020.World journal of diabetes · 2025Article
- Triglyceride-glucose Index and Mortality in a Large Regional-based Italian Database (URRAH Project).The Journal of clinical endocrinology and metabolism · 2025Article
- TyG-WC Index as a Superior Predictor of Hyperuricemia Risk in the Hypertensive Population: A Prospective Cohort Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Sex-specific associations between blood urea nitrogen and risk of hyperuricemia in U.S. adults: the NHANES 1999-2020.Frontiers in endocrinology · 2025Article
- Triglyceride-glucose index and its additive interaction withAnnals of medicine · 2024Article
- Association between anthropometric indices and hyperuricemia: a nationwide study in China.Clinical rheumatology · 2024Article
- The association between hyperuricemia and insulin resistance surrogates, dietary- and lifestyle insulin resistance indices in an Iranian population: MASHAD cohort study.Nutrition journal · 2024Article
- Sex-Based Differences in the Associations Between Obesity- and Lipid-Related Indexes and Hyperuricemia Risk in Patients with Obesity.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Nomogram for predicting reflux esophagitis with routine metabolic parameters: a retrospective study.Archives of medical science : AMS · 2024Article
- Comparison of seven anthropometric indexes to predict hypertension plus hyperuricemia among U.S. adults.Frontiers in endocrinology · 2024Article
- Article
- Triglyceride-Glucose Index is Significantly Associated with the Risk of Hyperuricemia in Patients with Nonalcoholic Fatty Liver Disease.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Correlation Analysis between Uric Acid and Metabolic Syndrome in the Chinese Elderly Population: A Cross-Sectional Study.International journal of endocrinology · 2023Article
- Association between MetS-IR and prediabetes risk and sex differences: a cohort study based on the Chinese population.Frontiers in endocrinology · 2023Article
- Positive correlation between fatty liver index and hyperuricemia in hypertensive Chinese adults: a H-type hypertension registry study.Frontiers in endocrinology · 2023Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveThe association between hyperuricemia and insulin resistance (IR) has been demonstrated by many studies, but the traditional IR indexes are too impractical to be used in clinical practice for the recognition of the IR state in individuals with hyperuricemia. Therefore, we aimed to further investigate the association between hyperuricemia and three non-insulin-based IR indexes in this large-scale cross-sectional study.
methodsA total of 174,695 adults without self-reported use of antihyperuricemic agents, hypoglycemic agents, or lipid-lowering drugs were included in the current analysis. The triglyceride to high-density lipoprotein cholesterol ratio (TG/HDLc), the product of fasting triglycerides and glucose (TyG), and metabolic score for IR (METS-IR) were calculated. Then, logistic regression analyses were applied to explore their association with hyperuricemia.
resultsThe TG/HDLc, TyG, and METS-IR all had positive correlations with uric acid level. However, only TG/HDLc and TyG were significantly associated with hyperuricemia in both sexes and body mass index (BMI) classification (the ORs of the highest quartile for each were 6.751 and 1.505 in females and 6.487 and 1.646 in males, respectively). The AUC values of TG/HDLc and TyG to discriminate hyperuricemia were also statistically significant in both sexes and BMI classification (all greater than 0.7).
conclusionsTG/HDLc and TyG are strongly associated with hyperuricemia regardless of BMI classification. These two obtainable and cost-effective non-insulin-based IR indexes could be potential monitors during the management of hyperuricemia and prevention of its IR-driven comorbidities. Key Points • In this large-scale study, we identified TG/HDLc and TyG as indicators for identification of IR in patients with hyperuricemia. • These simple and practical IR indicators are of substantial clinical importance for implementing preventive strategies against IR-driven comorbidities of hyperuricemia.
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