Evidence map›Paper›PMID 31300932›Full record

ArticleMagma (New York, N.Y.)2019

Validation of a novel blinding method for measuring postoperative knee articular cartilage using magnetic resonance imaging.

Rebecca Moyer, Trevor Birmingham, Felix Eckstein, Wolfgang Wirth, Susanne Maschek, Blaine Chronik, J Robert Giffin

Abstract readValidation Study
PubMed Publisher
In one paragraph

Article in Magma (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. High tibial osteotomy to neutral alignment improves medial knee articular cartilage composition.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2022
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 3 countries.

Rebecca MoyerFaculty of Health, School of Physiotherapy, Dalhousie University, 5869 University Ave, Forrest Building, PO Box 15000, Halifax, NS, B3H 4R2, Canada. rebecca.moyer@dal.ca.ORCID http://orcid.org/0000-0003-1719-4799
Trevor BirminghamWolf Orthopaedic Biomechanics Laboratory, Fowler Kennedy Sport Medicine Clinic, Western University, London, ON, Canada. tbirming@uwo.ca.
Felix EcksteinInstitute of Anatomy, Paracelsus Medical University Salzburg and Nuremberg, Salzburg, Austria.
Wolfgang WirthInstitute of Anatomy, Paracelsus Medical University Salzburg and Nuremberg, Salzburg, Austria.
Susanne MaschekInstitute of Anatomy, Paracelsus Medical University Salzburg and Nuremberg, Salzburg, Austria.
Blaine ChronikThe xMR Labs, Department of Physics and Astronomy, Western University, London, ON, Canada.
J Robert GiffinWolf Orthopaedic Biomechanics Laboratory, Fowler Kennedy Sport Medicine Clinic, Western University, London, ON, Canada.
Western University · CAParacelsus Medical University · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo test PEEK implant-associated MRI artifacts, a method for blinding MRI readers, the repeatability of cartilage thickness measures before and 6 weeks after high tibial osteotomy (HTO), and the sensitivity to change of cartilage thickness 12 months after HTO. MATERIALS AND

methodsTen patients underwent HTO using a PEEK implant and 3 T-MRI before, 6 weeks and 12 months after surgery. Masks were applied to hide implant visibility on 48 MRI pairs, which were assessed by 7 readers (blinded to time). One blinded reader measured femorotibial cartilage thickness from masked MRIs.

resultsNo artifacts were produced. Readers were unable to identify scans by time greater than by chance. Cartilage thickness before and 6 weeks after surgery was not significantly different and indicated excellent repeatability. Medial cartilage thickness increases 12 M postoperatively approached statistical significance (p = 0.06), with no lateral changes observed. Half of the participants had an increase in medial cartilage thickness at 12 M that exceeded the minimal detectable change. Standardized response mean values were moderate-to-large. DISCUSSION: Postoperative measures of cartilage thickness are repeatable, consistent and sensitive to change when artifact is eliminated, and a validated blinding technique is used. These results provide proof of concept for accurately measuring increases in medial knee articular cartilage after medial opening wedge HTO.

Indexed as

Magnetic Resonance ImagingArtifactsBenzophenonesCartilage, ArticularFemaleHumansImage Processing, Computer-AssistedKetonesKnee JointKnee ProsthesisMaleMiddle AgedObserver VariationOsteoarthritis, KneeOsteotomyPolyethylene GlycolsBenzophenonesKetonespolyetheretherketonePolyethylene GlycolsPolymersArticular cartilageKneeMagnetic resonance imagingOsteoarthritisOsteotomy

Identifiers

PMID31300932
OpenAlexW2956633204

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.