Evidence map›Paper›PMID 31300902›Full record

ArticleAMB Express2019

Preparation and characterization of a single-domain antibody specific for the porcine epidemic diarrhea virus spike protein.

Fuxiang Bao, Lixin Wang, Xinxin Zhao, Ting Lu, A Mi Na, Xuefei Wang, Jinshan Cao, Yanan Du

Open access · goldAbstract read
In one paragraph

Article in AMB Express, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Fuxiang BaoCollege of Veterinary Medicine, Inner Mongolia Agricultural University, No. 306, Zhaowuda Road, Saihan District, Huhhot, 010018, China.
Lixin WangCollege of Veterinary Medicine, Inner Mongolia Agricultural University, No. 306, Zhaowuda Road, Saihan District, Huhhot, 010018, China.
Xinxin ZhaoCollege of Veterinary Medicine, Inner Mongolia Agricultural University, No. 306, Zhaowuda Road, Saihan District, Huhhot, 010018, China.
Ting LuCollege of Veterinary Medicine, Inner Mongolia Agricultural University, No. 306, Zhaowuda Road, Saihan District, Huhhot, 010018, China.
A Mi NaCollege of Veterinary Medicine, Inner Mongolia Agricultural University, No. 306, Zhaowuda Road, Saihan District, Huhhot, 010018, China.
Xuefei WangCollege of Veterinary Medicine, Inner Mongolia Agricultural University, No. 306, Zhaowuda Road, Saihan District, Huhhot, 010018, China.
Jinshan CaoCollege of Veterinary Medicine, Inner Mongolia Agricultural University, No. 306, Zhaowuda Road, Saihan District, Huhhot, 010018, China. jinshancao@imau.edu.cn.
Yanan DuCollege of Veterinary Medicine, Inner Mongolia Agricultural University, No. 306, Zhaowuda Road, Saihan District, Huhhot, 010018, China. yanandu@126.com.
Inner Mongolia Agricultural University · CN

Funding

National Natural Science Foundation of China 81660297Research Program of Science and Technology at Universities of Inner Mongolia Autonomous Region NJZY069The Innovation Fund for Young Talent at College of Veterinary Medicine, Inner Mongolia Agricultural University 2015QNJJ01
6 · The paper itself

Abstract

Porcine epidemic diarrhea (PED) is a diarrheal disease of swine caused by porcine epidemic diarrhea virus (PEDV). It is characterized by acute watery diarrhea, dehydration and vomiting in swine of all ages and is especially fatal for neonatal and postweaning piglets. The spike protein of PEDV plays an important role in mediating virus attachment and fusion to target cells, and recent studies also reported that the neutralizing epitopes of the spike protein were mainly located in the S1 subunit, which makes it a candidate for vaccine development and clinical diagnosis. In this study, we successfully constructed an immune phage display single-domain antibody library with a library size of 3.4 × 10

Indexed as

Bactrian camelImmunofluorescenceNanobodyNeutralization activityPhage display antibody libraryPorcine epidemic diarrhea virus (PEDV)Single-domain antibodySpike protein

Identifiers

PMID31300902
PMCPMC6626092
OpenAlexW2962100168

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.