Evidence map›Paper›PMID 31300876›Full record

ArticleVirchows Archiv : an international journal of pathology2019

Immunohistochemical assessment of basal and luminal markers in non-muscle invasive urothelial carcinoma of bladder.

Maria Del Carmen Rodriguez Pena, Alcides Chaux, Marie-Lisa Eich, Aline C Tregnago, Diana Taheri, Walaa Borhan, Rajni Sharma, M Katayoon Rezaei, George J Netto

Abstract read
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In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.

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  8. Integrative Analysis ofInternational journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 4 countries.

Maria Del Carmen Rodriguez PenaDepartment of Pathology, The University of Alabama at Birmingham, WP Building, Suite P230, 619 19th Street South, Birmingham, AL, 35249-7331, USA.
Alcides ChauxDepartment of Scientific Research, School of Postgraduate Studies, Norte University, Asuncion, Paraguay.
Marie-Lisa EichDepartment of Pathology, The University of Alabama at Birmingham, WP Building, Suite P230, 619 19th Street South, Birmingham, AL, 35249-7331, USA.
Aline C TregnagoDepartment of Pathology, Johns Hopkins University, Baltimore, MD, 21287, USA.
Diana TaheriDepartment of Pathology, Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Walaa BorhanDepartment of Pathology, College of Medicine, Taibah University, Madinah, Saudi Arabia.
Rajni SharmaDepartment of Pathology, Johns Hopkins University, Baltimore, MD, 21287, USA.
M Katayoon RezaeiDepartment of Pathology, George Washington University, Washington, DC, 20037, USA.
George J NettoDepartment of Pathology, The University of Alabama at Birmingham, WP Building, Suite P230, 619 19th Street South, Birmingham, AL, 35249-7331, USA. gnetto@uabmc.edu.ORCID http://orcid.org/0000-0003-3915-9134
Johns Hopkins University · USUniversity of Alabama at Birmingham · USGeorge Washington University · USIsfahan University of Medical Sciences · IRTaibah University · SAUniversidad del Norte · PY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Cancer Genome Atlas project introduced genomic taxonomy of basal and luminal molecular subtypes in muscle invasive bladder cancer. Fewer studies have addressed the molecular classification in non-muscle invasive bladder cancer (NMIBC). Our aim is to assess the applicability of the proposed phenotypic classification for NMIBC. Three TMAs were constructed from 193 TURBT specimens of 60 bladder cancer patients treated at one of the authors' institutions (1998-2008). Follow-up data on recurrence, grade, or stage progression was obtained. Immunohistochemistry was performed using an automated Ventana System for markers indicative of luminal (GATA3, CK20, ER, Uroplakin II, and HER2/neu) and basal (CK5/6 and CD44) phenotype. Marker expression was evaluated by 3 urologic pathologists. Using unadjusted logistic regression, we found significant association between tumor recurrence at next biopsy and CD44 expression (OR = 2.51, P = 0.03), tumor recurrence at any subsequent biopsy and ER expression (OR = 0.24, P = 0.04), and tumor grade progression at any subsequent biopsy and HER2/neu expression (OR = 0.24, P = 0.04). After adjusting for pathologic stage, we found a significant association between CK5/6 expression and tumor stage progression at either next or any subsequent biopsy (OR = 0.94, P = 0.006; and OR = 0.97, P = 0.02, respectively). Our findings suggest that individual immunohistochemical markers may be of value as prognostic factors in NMIBC.

Indexed as

AgedAged, 80 and overBiomarkers, TumorCarcinoma in SituCarcinoma, Transitional CellFemaleGATA3 Transcription FactorHumansHyaluronan ReceptorsImmunohistochemistryKeratin-5MaleMiddle AgedNeoplasm InvasivenessNeoplasm Recurrence, LocalUrinary BladderBiomarkers, TumorCD44 protein, humanGATA3 protein, humanGATA3 Transcription FactorHyaluronan ReceptorsKeratin-5BasalImmunohistochemistryLuminalMolecular classificationNon-muscle invasive bladder cancerUrothelial carcinoma

Identifiers

PMID31300876
OpenAlexW2960850092

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.