Evidence map›Paper›PMID 31300843›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2019

Detection of high-risk human papillomavirus in the tonsils of galilee region adults and young adults undergoing tonsillectomy.

Reut Aviv Mordechai, Shay Steinberg, Liat Apel-Sarid, Ety Shaoul, Simona Zisman Rozen, Lubna Khoury, Ohad Ronen

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Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Reut Aviv MordechaiAzrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.
Shay SteinbergAzrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.
Liat Apel-SaridDepartment of Pathology, Galilee Medical Center, Nahariya, Israel.
Ety ShaoulDepartment of Hematology, Galilee Medical Center, Nahariya, Israel.
Simona Zisman RozenDepartment of Hematology, Galilee Medical Center, Nahariya, Israel.
Lubna KhouryDepartment of Hematology, Galilee Medical Center, Nahariya, Israel.
Ohad RonenHead and Neck Surgery Unit, Department of Otolaryngology-Head and Neck Surgery, Galilee Medical Center, POB 21, 2210001, Nahariya, Israel. ohadr@gmc.gov.il.ORCID http://orcid.org/0000-0001-7084-0695
Western Galilee Hospital · ILBar-Ilan University · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe presence of high-risk HPV in non-malignant tonsil tissues from patients who underwent tonsillectomy in the Galilee area might explain the low incidence of HPV-related oropharyngeal malignancy in the country. The aim of this retrospective study was to study the prevalence of human papillomavirus (HPV) in non-malignant tonsillectomy specimens of adults in the Galilee area. MATERIALS AND

methodsWe conducted a retrospective analysis of all tonsil samples in our medical center. Tonsils from patients over 20 years of age who underwent tonsillectomy for the indication of recurrent tonsillitis and sleep apneas were eligible. Samples of formalin-fixed paraffin-embedded (FFPE) tonsillar tissue were tested for the presence of HPV DNA using polymerase chain reaction and by p16 immunohistochemistry.

resultsOf the 71 tonsil samples, age range 20-65, none were positive for HPV DNA. Fifty-two FFPE specimens of tonsil with HPV-positive cancer tested positive by the same method served as positive controls.

conclusionsHPV DNA is rare in non-malignant tonsil tissues of young adults and adults who underwent tonsillectomy in the Galilee area. Further research should be done in larger cohorts.

Indexed as

PapillomaviridaePapillomavirus InfectionsTonsillitisAdultCyclin-Dependent Kinase Inhibitor p16DNA, ViralFemaleHumansImmunohistochemistryIsraelMaleMiddle AgedPalatine TonsilPrevalenceRetrospective StudiesTonsillectomyCDKN2A protein, humanCyclin-Dependent Kinase Inhibitor p16DNA, ViralHuman papillomavirusPrevalenceTonsillectomy

Identifiers

PMID31300843
OpenAlexW2956689187

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.