ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2020
Community-acquired Bacterial Meningitis in Adults With Cerebrospinal Fluid Leakage.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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24 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Pneumococcal Vaccine for Adults Aged ≥19 Years: Recommendations of the Advisory Committee on Immunization Practices, United States, 2023.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2023Guideline
- Sutured versus Sutureless Dural Substitutes: Experience from a Government Tertiary Care Hospital in India.Asian journal of neurosurgery · 2026Article
- Recurrent Pneumococcal Meningitis From Post-traumatic Frontoethmoidal Encephalocele: A Case Report.Cureus · 2025Article
- Unraveling a Diagnostic Enigma: Navigating an Intricate Case of Spontaneous Cerebrospinal Fluid Rhinorrhea.Maedica · 2025Article
- Postendoscopic spine surgery bacterial meningitis requiring multiple surgical interventions: A complex case report.Radiology case reports · 2024Article
- How I do it: single-staged emergency neurosurgical management of frontal penetrating craniocerebral injury with depressed skull fracture.Acta neurochirurgica · 2024Article
- Cribriform plate dehiscence with encephalomeningocele revealed by recurrent meningitis: A case report.La Tunisie medicale · 2024Article
- Invasive Pneumococcal Disease and COVID-19 With Acute Otitis Media and a Tegmen Tympani Defect.Cureus · 2023Article
- Risk factors and cerebrospinal fluid indexes analysis of intracranial infection by Acinetobacter baumannii after neurosurgery.Heliyon · 2023Article
- Bacterial meningitis in children with an abnormal craniocerebral structure.Frontiers in pediatrics · 2023Article
- Temporal Bone Skull Base Defects-The Value and Importance of Early Based Detection to Prevent Late Costly Morbidity and Mortality.Journal of neurological surgery. Part B, Skull base · 2022Review
- Relationship between T-cell-dependent and T-cell-independent vaccines after neurotrauma; is the B-cell response preserved?Human vaccines & immunotherapeutics · 2022Article
- Healthy adults withThe Journal of international medical research · 2022Review
- Article
- Diagnostic Value of Radioisotope Cisternography UsingMedicina (Kaunas, Lithuania) · 2022Review
- The gut-meningeal immune axis: Priming brain defense against the most likely invaders.The Journal of experimental medicine · 2022Review
- High efficacy of tetra-PEG hydrogel sealants for sutureless dural closure.Bioactive materials · 2022Article
- Analysis of risk factors and preventive strategies for intracranial infection after neuroendoscopic transnasal pituitary adenoma resection.BMC neuroscience · 2022Article
- Lumbar Cistern Drainage and Gentamicin Intrathecal Injection in the Treatment of Carbapenem-Resistant Klebsiella Pneumoniae Intracranial Infection After Intracerebral Hemorrhage craniotomy: A Case Report.Infection and drug resistance · 2022Article
- Predisposing conditions for bacterial meningitis in children: what radiologists need to know.Japanese journal of radiology · 2022Review
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCerebrospinal fluid (CSF) leakage is a risk factor for developing bacterial meningitis.
methodsWe analyzed episodes of community-acquired bacterial meningitis associated with CSF leakage from a prospective nationwide cohort study.
resultsCSF leakage was identified in 65 episodes of 2022 episodes (3%) in 53 patients. The cause of CSF leakage was identified in 49 of 65 episodes (75%), which most commonly consisted of ear-nose-throat surgery (19 of 49 episodes [29%]) and remote head trauma (15 of 49 episodes [23%]). The episode was a recurrent meningitis episode in 38 patients (59%). Of the recurrent episodes, 27 had known CSF leakage (71%) of whom 20 (53%) had previous surgery aiming to close the leak. Nine patients (38%) with known CSF leakage had been vaccinated (23-valent pneumococcal vaccine in 9 patients, meningococcal serogroup C vaccine in 2, meningococcal serogroup A and Haemophilus influenzae type b vaccine each in 1 patient). Streptococcus pneumoniae was cultured in 33 episodes (51%) and H. influenzae in 11 episodes (17%). The most common pneumococcal serotypes were 3 (4 episodes), 35B, 9N, 38, and 15C (each 2 episodes). Haemophilus influenzae was unencapsulated in all 10 episodes with known capsule type. The outcome was unfavorable in 8 episodes (12%) and no patient died.
conclusionsBacterial meningitis in patients with CSF leakage has a high recurrence rate, despite surgical repair or vaccination, and outcome is generally favorable. CSF leakage should be suspected in patients with bacterial meningitis presenting with liquorrhea, recurrent meningitis, or with disease caused by H. influenzae.
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