Evidence map›Paper›PMID 31300708›Full record

Observational studyScientific reports2019

Incremental Peritoneal Dialysis May be Beneficial for Preserving Residual Renal Function Compared to Full-dose Peritoneal Dialysis.

Yeonhee Lee, Sung Won Chung, Seokwoo Park, Hyunjin Ryu, Hajeong Lee, Dong Ki Kim, Kwon Wook Joo, Curie Ahn, Joongyub Lee, Kook-Hwan Oh

Registry-linked trialAbstract readObservational Study
In one paragraph

Observational study in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05721404 (Icodextrin Postpones the Shift of Low Dose to Full Dose Dialysis in the First Year of Incremental Peritoneal Dialysis), which is not on this map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05721404 phase4recruitingnot on this mapstarted 2023, after this paper: background citation

Icodextrin Postpones the Shift of Low Dose to Full Dose Dialysis in the First Year of Incremental Peritoneal Dialysis: A Randomized Controlled Trial

TypeinterventionalSponsorFirst Affiliated Hospital, Sun Yat-Sen UniversityRan2023 to 2027Enrolled194ConditionsPeritoneal DialysisArmsIcodextrin Peritoneal Dialysis Solution, Hypertonic Dextrose solution
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Vadadustat for anemia in chronic kidney disease patients on peritoneal dialysis: A phase 3 open-label study in Japan.Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2021
    Trial
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  14. Dialysis in the Elderly: A Practical Guide for the Clinician.International journal of nephrology · 2025
    Review
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  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yeonhee LeeDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Sung Won ChungDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.ORCID http://orcid.org/0000-0001-7263-6866
Seokwoo ParkDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Hyunjin RyuDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Hajeong LeeDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Dong Ki KimDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.ORCID http://orcid.org/0000-0002-5195-7852
Kwon Wook JooDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Curie AhnDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.ORCID http://orcid.org/0000-0001-7033-1102
Joongyub LeePrevention and Management Center, Inha University Hospital, Incheon, Korea. tp240@naver.com.
Kook-Hwan OhDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. khoh@snu.ac.kr.ORCID http://orcid.org/0000-0001-9525-2179

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Maintaining residual renal function (RRF) is a crucial issue in peritoneal dialysis (PD). Incremental dialysis is the practice of initiating PD exchanges less than four times a day in consideration of RRF, and increasing dialysis dose in a step-wise manner as the RRF decreases. We aimed to compare the outcomes of incremental PD and full-dose PD in terms of RRF preservation and other outcomes. This was a single-center, observational study. Data were extracted retrospectively from a cohort of incident PD patients over 16 years old who started PD between 2007 and 2015 in the PD Unit of Seoul National University Hospital. We used inverse probability weighting (IPW) adjustment based on propensity scores to balance covariates between the incremental and full-dose PD groups. Multivariate, time-dependent Cox analyses were performed. Among 347 incident PD patients, 176 underwent incremental PD and 171 underwent conventional full-dose PD. After IPW adjustment, the incremental PD group exhibited a lower risk of developing anuria (hazard ratio [HR] 0.61, 95% confidence interval [CI] 0.43-0.88). Patient survival, technique survival, and peritonitis-free survival were all similar between these groups (P > 0.05 by log-rank test). Incremental PD was beneficial for preserving RRF and showed similar patient survival when compared to conventional full-dose PD.

Indexed as

AnuriaFemaleGlomerular Filtration RateHumansKidney Failure, ChronicMaleMiddle AgedPeritoneal DialysisPeritonitisRetrospective Studies

Identifiers

PMID31300708
PMCPMC6626037

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.