Evidence map›Paper›PMID 31300649›Full record

ArticleNature communications2019

Dual-color fluorescent nanoparticles showing perfect color-specific photoswitching for bioimaging and super-resolution microscopy.

Dojin Kim, Keunsoo Jeong, Ji Eon Kwon, Hyeonjong Park, Seokyung Lee, Sehoon Kim, Soo Young Park

Abstract read
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

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  12. Recent Progress in Photoresponsive Biomaterials.Molecules (Basel, Switzerland) · 2023
    Review
  13. Nanoparticle-Based Techniques for Bladder Cancer Imaging: A Review.International journal of molecular sciences · 2023
    Review
  14. Review
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dojin KimCenter for Supramolecular Optoelectronic Materials, Research Institute of Advanced Materials (RIAM), Department of Materials Science and Engineering, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Korea.ORCID http://orcid.org/0000-0002-5647-1659
Keunsoo JeongCenter for Theragnosis, Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, Seoul, 02792, Korea.ORCID http://orcid.org/0000-0001-8373-3418
Ji Eon KwonCenter for Supramolecular Optoelectronic Materials, Research Institute of Advanced Materials (RIAM), Department of Materials Science and Engineering, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Korea.ORCID http://orcid.org/0000-0001-5382-3690
Hyeonjong ParkCenter for Theragnosis, Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, Seoul, 02792, Korea.
Seokyung LeeCenter for Theragnosis, Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, Seoul, 02792, Korea.
Sehoon KimCenter for Theragnosis, Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, Seoul, 02792, Korea.ORCID http://orcid.org/0000-0002-8074-1006
Soo Young ParkCenter for Supramolecular Optoelectronic Materials, Research Institute of Advanced Materials (RIAM), Department of Materials Science and Engineering, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Korea. parksy@snu.ac.kr.

Funding

Korea Research Institute of Standards and Science (KRISS) KRISS-2018-GP2018-0018Ministry of Science, ICT and Future Planning (MSIP) Grant No. 2009-0081571[RIAM0417-20150013]Ministry of Science, ICT and Future Planning (MSIP) Grant No. 2017R1E1A1A01075372
6 · The paper itself

Abstract

Dual-emissive systems showing color-specific photoswitching are promising in bioimaging and super-resolution microscopy. However, their switching efficiency has been limited because a delicate manipulation of all the energy transfer crosstalks in the systems is unfeasible. Here, we report a perfect color-specific photoswitching, which is rationally designed by combining the complete off-to-on fluorescence switching capability of a fluorescent photochromic diarylethene and the frustrated energy transfer to the other fluorescent dye based on the excited-state intramolecular proton transfer (ESIPT) process. Upon alternation of UV and visible light irradiations, the system achieves 100% switching on/off of blue emission from the diarylethene while orange emission from the ESIPT dye is unchanged in the polymer film. By fabricating this system into biocompatible polymer nanoparticles, we demonstrate microscopic imaging of RAW264.7 macrophage cells with reversible blue-color specific fluorescence switching that enables super-resolution imaging with a resolution of 70 nm.

Indexed as

AnimalsBiocompatible MaterialsColorEnergy TransferFluorescenceFluorescent DyesIntravital MicroscopyLightMiceMicroscopy, Electron, TransmissionMicroscopy, FluorescenceMolecular ImagingNanoparticlesPolymersRAW 264.7 CellsBiocompatible MaterialsFluorescent DyesPolymers

Identifiers

PMID31300649
PMCPMC6626011

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.