Evidence map›Paper›PMID 31300556›Full record

ArticleThe Journal of biological chemistry2019

Unlike the

Matilde Clarissa Malfatti, Ghislaine Henneke, Sathya Balachander, Kyung Duk Koh, Gary Newnam, Ryo Uehara, Robert J Crouch, Francesca Storici, Gianluca Tell

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. Ribonucleotide errors, RNase HII, and ribonucleotide excision repair.Critical reviews in biochemistry and molecular biology · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. bioRxiv : the preprint server for biology · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. RNA abasic sites in yeast and human cells.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  11. Impact of 1,The Journal of biological chemistry · 2020
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 4 countries.

Matilde Clarissa MalfattiLaboratory of Molecular Biology and DNA Repair, Department of Medicine, University of Udine, 33100 Udine, Italy.
Ghislaine HennekeIfremer, Univ Brest, CNRS, Laboratoire de Microbiologie des Environnements Extrêmes, F-29280 Plouzané, France.
Sathya BalachanderSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332.
Kyung Duk KohSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332.
Gary NewnamSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332.
Ryo UeharaRitsumeikan Global Innovation Research Organization, Ritsumeikan University, 1-1-1 Noji-higashi, Kusatsu, Shiga 525-8577, Japan.
Robert J CrouchDivision of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892.
Francesca StoriciSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332.
Gianluca TellLaboratory of Molecular Biology and DNA Repair, Department of Medicine, University of Udine, 33100 Udine, Italy. Electronic address: gianluca.tell@uniud.it.
Georgia Institute of Technology · USUniversity of Udine · ITCentre National de la Recherche Scientifique · FRNational Institutes of Health · USRitsumeikan University · JP

Funding

Factors Influencing Genetic Transcription Initiation And TerminationZIAHD000068 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI CROUCH, ROBERT J · 2009 to 2025
$22.0M
Ribose-seq profile and analysis of ribonucleotides in DNA of oxidatively-stressed and cancer cellsR01ES026243 · NIEHS · GEORGIA INSTITUTE OF TECHNOLOGY · PI STORICI, FRANCESCA · 2016 to 2020
$1.4M
Howard Hughes Medical Institute 55108574NIEHS NIH HHS R01 ES026243
6 · The paper itself

Abstract

The presence of ribonucleoside monophosphates (rNMPs) in nuclear DNA decreases genome stability. To ensure survival despite rNMP insertions, cells have evolved a complex network of DNA repair mechanisms, in which the ribonucleotide excision repair pathway, initiated by type 2 RNase H (RNase HII/2), plays a major role. We recently demonstrated that eukaryotic RNase H2 cannot repair damage, that is, ribose monophosphate abasic (both apurinic or apyrimidinic) site (rAP) or oxidized rNMP embedded in DNA. Currently, it remains unclear why RNase H2 is unable to repair these modified nucleic acids having either only a sugar moiety or an oxidized base. Here, we compared the endoribonuclease specificity of the RNase HII enzymes from the archaeon

Indexed as

DNAEscherichia coliHeLa CellsHumansOxidation-ReductionRibonuclease HRibonucleotidesRibosemonophosphatesTumor Cells, CulturedDNARibonuclease Hribonuclease HIIRibonucleotidesribose-5-phosphateRibosemonophosphatesabasic-ribosearchaeabacteriaEscherichia coli (E. coli)oxidative stressoxidized-ribonucleotidesPyrococcus abyssiribonucleaseType 2 RNase H

Identifiers

PMID31300556
PMCPMC6721941
OpenAlexW2957711665

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.