Evidence map›Paper›PMID 31300542›Full record

ArticleeNeuro

Fluctuating Regional Brainstem Diffusion Imaging Measures of Microstructure across the Migraine Cycle.

Kasia K Marciszewski, Noemi Meylakh, Flavia Di Pietro, Vaughan G Macefield, Paul M Macey, Luke A Henderson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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  4. Article
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  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Neurite Damage in Patients with Migraine.Neurology international · 2024
    Article
  12. Review
  13. Article
  14. Article
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  16. Article
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  18. Article
  19. Article
  20. Chronic Migraine Pathophysiology and Treatment: A Review of Current Perspectives.Frontiers in pain research (Lausanne, Switzerland) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kasia K MarciszewskiDepartment of Anatomy and Histology, Sydney Medical School, University of Sydney, Sydney, 2006 New South Wales, Australia.
Noemi MeylakhDepartment of Anatomy and Histology, Sydney Medical School, University of Sydney, Sydney, 2006 New South Wales, Australia.ORCID 0000-0002-2144-4028
Flavia Di PietroDepartment of Anatomy and Histology, Sydney Medical School, University of Sydney, Sydney, 2006 New South Wales, Australia.ORCID 0000-0002-9642-0805
Vaughan G MacefieldSchool of Medicine, Western Sydney University, Campbelltown, 2560 New South Wales, Australia.ORCID 0000-0003-3325-6566
Paul M MaceyUniversity of California, Los Angeles School of Nursing and Brain Research Institute, University of California, Los Angeles, CA 90095.ORCID 0000-0003-4093-7458
Luke A HendersonDepartment of Anatomy and Histology, Sydney Medical School, University of Sydney, Sydney, 2006 New South Wales, Australia lukeh@anatomy.usyd.edu.au.ORCID 0000-0002-1026-0151

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The neural mechanisms responsible for the initiation and expression of migraines remain unknown. Although there is growing evidence of changes in brainstem anatomy and function between attacks, very little is known about brainstem function and structure in the period immediately prior to a migraine. The aim of this investigation is to use brainstem-specific analyses of diffusion weighted images to determine whether the brainstem pain processing regions display altered structure in individuals with migraine across the migraine cycle, and in particular immediately prior to a migraine. Diffusion tensor images (29 controls, 36 migraineurs) were used to assess brainstem anatomy in migraineurs compared with controls. We found that during the interictal phase, migraineurs displayed greater mean diffusivity (MD) in the region of the spinal trigeminal nucleus (SpV), dorsomedial pons (dmPons)/dorsolateral pons (dlPons), and midbrain periaqueductal gray matter (PAG)/cuneiform nucleus (CNF). Remarkably, the MD returned to controls levels during the 24-h period immediately prior to a migraine, only to increase again within the three following days. Additionally, fractional anisotropy (FA) was significantly elevated in the region of the medial lemniscus/ventral trigeminal thalamic tract in migraineurs compared with controls over the entire migraine cycle. These data show that regional brainstem anatomy changes over the migraine cycle, with specific anatomical changes occurring in the 24-h period prior to onset. These changes may contribute to the activation of the ascending trigeminal pathway by either an increase in basal traffic or by sensitizing the trigeminal nuclei to external triggers, with activation ultimately resulting in perception of head pain during a migraine attack.

Indexed as

AdultBrain StemDiffusion Tensor ImagingFemaleHumansMaleMigraine DisordersPainPain Measurementbrainstemdiffusion tensor imagingmigraineMRIPAGspinal trigeminal nucleus

Identifiers

PMID31300542
PMCPMC6658917

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.