Evidence map›Paper›PMID 31300540›Full record

ArticleMolecular cancer research : MCR2019

Loss of MAP3K7 Sensitizes Prostate Cancer Cells to CDK1/2 Inhibition and DNA Damage by Disrupting Homologous Recombination.

Satoshi Washino, Leah C Rider, Lina Romero, Lauren K Jillson, Trisiani Affandi, Angela M Ohm, Elaine T Lam, Mary E Reyland, James C Costello, Scott D Cramer

Open access · bronzeAbstract read
In one paragraph

Article in Molecular cancer research : MCR, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Frontiers in oncology · 2022
    Article
  6. Molecular cancer research : MCR · 2021
    Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Molecular therapy oncolytics · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Satoshi WashinoDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Leah C RiderDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Lina RomeroDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Lauren K JillsonDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Trisiani AffandiDepartment of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.ORCID 0000-0002-2307-0357
Angela M OhmDepartment of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.ORCID 0000-0002-4495-5103
Elaine T LamDepartment of Internal Medicine, Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Mary E ReylandDepartment of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
James C Costello *Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.ORCID 0000-0003-3158-9682
Scott D Cramer *Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, Colorado. Scott.cramer@ucdenver.edu.
University of Colorado Anschutz Medical Campus · US

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
Paul Calabresis Award in Clinical Oncology ResearchK12CA086913 · NCI · UNIVERSITY OF COLORADO DENVER · PI VIRGINIA F. BORGES, Jill E Slansky · 2000 to 2026
$17.8M
Training Program in Cancer BiologyT32CA190216 · NCI · UNIVERSITY OF COLORADO DENVER · PI Craig T. Jordan · 2016 to 2026
$3.5M
Systems analysis of aggressive prostate cancer pathologyU01CA231978 · NCI · UNIVERSITY OF COLORADO DENVER · PI COSTELLO, JAMES CHRISTOPHER, CRAMER, SCOTT D · 2019 to 2023
$3.4M
CHD1 and MAP3K7 coordinate deletion in aggressive ERG translocation negative prostate cancerR01CA199741 · NCI · UNIVERSITY OF COLORADO DENVER · PI CRAMER, SCOTT D · 2015 to 2019
$1.8M
CHD1 and TAK1 Synthetic Lethality in Prostate CancerR21CA187354 · NCI · UNIVERSITY OF COLORADO DENVER · PI CRAMER, SCOTT D · 2015 to 2016
$372k
NCI NIH HHS K12 CA086913NCI NIH HHS P30 CA046934NCI NIH HHS R01 CA199741NCI NIH HHS R21 CA187354NCI NIH HHS T32 CA190216NCI NIH HHS U01 CA231978
6 · The paper itself

Abstract

The combined loss of

Indexed as

Cell Line, TumorDNA DamageHomologous RecombinationHumansMaleMAP Kinase Kinase Kinase 7MAP Kinase Kinase KinasesProstatic NeoplasmsMAP Kinase Kinase Kinase 7MAP Kinase Kinase Kinases

Identifiers

PMID31300540
PMCPMC7266379
OpenAlexW2958507308

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.