Evidence map›Paper›PMID 31300527›Full record

ArticleBioscience reports2019

Insulin resistance in prostate cancer patients and predisposing them to acute ischemic heart disease.

Udayan Ray, Sarbashri Bank, Madawa W Jayawardana, Jahar Bhowmik, Frank Redwig, Pradipta Jana, Suman Bhattacharya, Emili Manna, Subrata Kumar De, Smarajit Maiti and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioscience reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. O-GlcNAcylation: Crosstalk between Hemostasis, Inflammation, and Cancer.International journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 3 countries.

Udayan RayDepartment of Pathology, The Royal Hobart Hospital, Tasmania, Australia sbank.biochem@gmail.com rudayan@hotmail.com mjayawardana@swin.edu.au.
Sarbashri BankDepartment of Biochemistry, Sinha Institute of Medical Science and Technology, Kolkata, India sbank.biochem@gmail.com rudayan@hotmail.com mjayawardana@swin.edu.au.ORCID 0000-0001-9603-1415
Madawa W JayawardanaDepartment of Statistics, Data Science and Epidemiology, Swinburne University of Technology, Melbourne, Australia sbank.biochem@gmail.com rudayan@hotmail.com mjayawardana@swin.edu.au.
Jahar BhowmikDepartment of Statistics, Data Science and Epidemiology, Swinburne University of Technology, Melbourne, Australia.
Frank RedwigDepartment of Pathology, The Royal Hobart Hospital, Tasmania, Australia.
Pradipta JanaDepartment of Botany, University of Calcutta, West Bengal, Kolkota, India.
Suman BhattacharyaDepartment of Biochemistry, Sinha Institute of Medical Science and Technology, Kolkata, India.
Emili MannaCentre for Life Sciences, Vidyasagar University, Medinipur, West Bengal, India.
Subrata Kumar DeDepartment of Biochemistry, Sinha Institute of Medical Science and Technology, Kolkata, India.
Smarajit MaitiDeptartment of Biochemistry, OIST, Vidyasagar University, Medinipur, West Bengal, India.
Philip Roberts-ThomsonDepartment of Pathology, The Royal Hobart Hospital, Tasmania, Australia.
Venkat ParameswaranDepartment of Pathology, The Royal Hobart Hospital, Tasmania, Australia.
Asru K SinhaDepartment of Biochemistry, Sinha Institute of Medical Science and Technology, Kolkata, India.
Royal Hobart Hospital · AUVidyasagar University · INSwinburne University of Technology · AUSinha Institute of Medical Science & Technology · INUniversity of Calcutta · INUniversity of Kansas · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lack of insulin or insulin resistance (IR) plays a central role in diabetes mellitus and makes diabetics prone to acute ischemic heart disease (AIHD). It has likewise been found that many cancer patients, including prostate cancer patients die of AIHD. Previously it has been delineated from our laboratory that dermcidin could induce anomalous platelet aggregation in AIHD and also impaired nitric oxide and insulin activity and furthermore dermcidin was also found in a few types of cancer patients. To determine the role of this protein in prostatic malignancy, a retrospective case-control study was conducted and blood was collected from prostate cancer patients and healthy normal volunteers. So, we measured the level of dermcidin protein and analyzed the IR by Homeostasis Model Assessment (HOMA) score calculation. Nitric oxide was measured by methemoglobin method. HDL, glycated hemoglobin (HbA1c), BMI, hs-cTroponin-T were measured for the validation of the patients' status in the presence of Dermcidin isoform-2 (DCN-2). Multiple logistic regression model adjusted for age and BMI identified that the HOMA score was significantly elevated in prostate cancer patients (OR = 7.19,

Indexed as

Insulin ResistanceModels, CardiovascularMyocardial IschemiaProstatic NeoplasmsAcute DiseaseAgedGlycated HemoglobinHumansLipoproteins, HDLMaleMiddle AgedNeoplasm ProteinsPeptidesTroponin TdermcidinGlycated Hemoglobinhemoglobin A1c protein, humanLipoproteins, HDLNeoplasm ProteinsPeptidesTroponin TdermcidinHOMA scorehs-cTropononTinsulin resistancenitric oxideprostate cancer

Identifiers

PMID31300527
PMCPMC6663988
OpenAlexW2961370542

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.