ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019
Distinct Heterosynaptic Plasticity in Fast Spiking and Non-Fast-Spiking Inhibitory Neurons in Rat Visual Cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 31 citations in OpenAlex.
- Group I metabotropic glutamate receptors differentially modulate excitatory transmission across interneuron types in the human cortex.Frontiers in synaptic neuroscience · 2026Article
- Plasticity of Response Properties of Mouse Visual Cortex Neurons Induced by Optogenetic Tetanization In Vivo.Current issues in molecular biology · 2024Article
- Wired together, change together: Spike timing modifies transmission in converging assemblies.Science advances · 2024Article
- The spike-timing-dependent plasticity of VIP interneurons in motor cortex.Frontiers in cellular neuroscience · 2024Article
- Heterosynaptic plasticity-induced modulation of synapses.The journal of physiological sciences : JPS · 2023Review
- Enhanced Non-Associative Long-Term Potentiation in Immature Granule Cells in the Dentate Gyrus of Adult Rats.Frontiers in synaptic neuroscience · 2022Article
- Brain is modulated by neuronal plasticity during postnatal development.The journal of physiological sciences : JPS · 2021Review
- Mechanism of Pacemaker Activity in Zebrafish DC2/4 Dopaminergic Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Structural and Functional Synaptic Plasticity Induced by Convergent Synapse Loss in theThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Heterosynaptic Plasticity and the Experience-Dependent Refinement of Developing Neuronal Circuits.Frontiers in neural circuits · 2021Review
- Heterosynaptic Plasticity in Cortical Interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- The CSF-Contacting Nucleus Receives Anatomical Inputs From the Cerebral Cortex: A Combination of Retrograde Tracing and 3D Reconstruction Study in Rat.Frontiers in neuroanatomy · 2020Article
- Synaptic Plasticity in Cortical Inhibitory Neurons: What Mechanisms May Help to Balance Synaptic Weight Changes?Frontiers in cellular neuroscience · 2020Review
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7 authors at 3 institutions in 3 countries.
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Abstract
Inhibition in neuronal networks of the neocortex serves a multitude of functions, such as balancing excitation and structuring neuronal activity in space and time. Plasticity of inhibition is mediated by changes at both inhibitory synapses, as well as excitatory synapses on inhibitory neurons. Using slices from visual cortex of young male rats, we describe a novel form of plasticity of excitatory synapses on inhibitory neurons, weight-dependent heterosynaptic plasticity. Recordings from connected pyramid-to-interneuron pairs confirm that postsynaptic activity alone can induce long-term changes at synapses that were not presynaptically active during the induction, i.e., heterosynaptic plasticity. Moreover, heterosynaptic changes can accompany homosynaptic plasticity induced in inhibitory neurons by conventional spike-timing-dependent plasticity protocols. In both fast-spiking (FS) and non-FS neurons, heterosynaptic changes were weight-dependent, because they correlated with initial paired-pulse ratio (PPR), indicative of initial strength of a synapse. Synapses with initially high PPR, indicative of low release probability ("weak" synapses), had the tendency to be potentiated, while synapses with low initial PPR ("strong" synapses) tended to depress or did not change. Interestingly, the net outcome of heterosynaptic changes was different in FS and non-FS neurons. FS neurons expressed balanced changes, with gross average (
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