Evidence map›Paper›PMID 31300474›Full record

ArticleCancer research2019

Integrative Genomic Characterization Identifies Molecular Subtypes of Lung Carcinoids.

Saurabh V Laddha, Edaise M da Silva, Kenneth Robzyk, Brian R Untch, Hua Ke, Natasha Rekhtman, John T Poirier, William D Travis, Laura H Tang, Chang S Chan

Abstract read
In one paragraph

Article in Cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  18. Neuroendocrine neoplasms of the lung: The latest updates.World journal of clinical oncology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Saurabh V LaddhaRutgers Cancer Institute of New Jersey, Rutgers University, New Brunswick, New Jersey.ORCID 0000-0002-8781-9478
Edaise M da SilvaDepartment of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York.
Kenneth RobzykDepartment of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York.
Brian R UntchDepartment of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York.
Hua KeRutgers Cancer Institute of New Jersey, Rutgers University, New Brunswick, New Jersey.
Natasha RekhtmanDepartment of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York.
John T PoirierThoracic Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, New York.ORCID 0000-0001-9795-5644
William D TravisDepartment of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York.
Laura H TangDepartment of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York. chanc3@cinj.rutgers.edu tangl@mskcc.org.
Chang S ChanRutgers Cancer Institute of New Jersey, Rutgers University, New Brunswick, New Jersey. chanc3@cinj.rutgers.edu tangl@mskcc.org.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
TRANSCRIPTIONAL PROFILINGP30CA072720 · NCI · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI Chang S Chan · 1997 to 2026
$94.5M
Supercomputing: Rutgers' Catalyst for Discovery at the Frontiers of MedicineS10OD012346 · OD · RBHS-NEW JERSEY MEDICAL SCHOOL · PI MICHELSON, LESLIE PAUL · 2015 to 2015
$1.7M
NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA072720NIH HHS S10 OD012346
6 · The paper itself

Abstract

Lung carcinoids (LC) are rare and slow growing primary lung neuroendocrine tumors. We performed targeted exome sequencing, mRNA sequencing, and DNA methylation array analysis on macro-dissected LCs. Recurrent mutations were enriched for genes involved in covalent histone modification/chromatin remodeling (34.5%;

Indexed as

Basic Helix-Loop-Helix ProteinsBiomarkers, TumorCarcinoid TumorCell CycleCohort StudiesDNA MethylationEpigenesis, GeneticGene Expression ProfilingGene Expression Regulation, NeoplasticHumansLung NeoplasmsMutationProto-Oncogene ProteinsReproducibility of ResultsRNA, MessengerS100 ProteinsASCL1 protein, humanBasic Helix-Loop-Helix ProteinsBiomarkers, TumorMEN1 protein, humanProto-Oncogene ProteinsRNA, MessengerS100 Proteins

Identifiers

PMID31300474
PMCPMC6733269

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.