Evidence map›Paper›PMID 31300450›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2019

Analysis of Cell-Free DNA from 32,989 Advanced Cancers Reveals Novel Co-occurring Activating

Thereasa A Rich, Karen L Reckamp, Young Kwang Chae, Robert C Doebele, Wade T Iams, Michael Oh, Victoria M Raymond, Richard B Lanman, Jonathan W Riess, Thomas E Stinchcombe and 5 more

Open access · greenAbstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
4.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 89 citations in OpenAlex.

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  13. Cancers · 2023
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  16. Precision oncology with selective RET inhibitor selpercatinib inTherapeutic advances in medical oncology · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Thereasa A Rich *Guardant Health, Redwood City, California. trich@guardanthealth.com.
Karen L Reckamp *Department of Medical Oncology & Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, California.
Young Kwang ChaeDepartment of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Robert C DoebeleMedical Oncology/Department of Medicine, University of Colorado Cancer Center, Aurora, Colorado.
Wade T IamsDivision of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Michael OhDepartment of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Victoria M RaymondGuardant Health, Redwood City, California.
Richard B LanmanGuardant Health, Redwood City, California.
Jonathan W RiessDivision of Hematology/Oncology, University of California Davis Comprehensive Cancer Center, Sacramento, California.
Thomas E StinchcombeDepartment of Medicine, Duke Cancer Institute, Durham, North Carolina.
Vivek SubbiahDepartment of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
David R TrevarthenDepartment of Hematology/Oncology, Comprehensive Cancer Care and Research Institute of Colorado, Englewood, Colorado.
Stephen FaircloughGuardant Health, Redwood City, California.
Jennifer YenGuardant Health, Redwood City, California.
Oliver GautschiUniversity of Berne and Department of Medicine, Cantonal Hospital Lucerne, Lucerne, Switzerland.
Northwestern University · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
Staff InvestigatorsP30CA093373 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI Gina M Dayton · 2002 to 2026
$84.9M
Vanderbilt Clinical Oncology Research Career Development ProgramK12CA090625 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Debra L. Friedman, Paula Jill Hurley · 2001 to 2026
$16.9M
NCI NIH HHS K12 CA090625NCI NIH HHS P30 CA016672NCI NIH HHS P30 CA093373
6 · The paper itself

Abstract

purposeEXPERIMENTAL

designSomatic activating

resultsA total of 176 somatic activating

conclusionsIn the largest cancer cohort with somatic activating

Indexed as

MutationCirculating Tumor DNACohort StudiesHigh-Throughput Nucleotide SequencingHumansNeoplasmsNeoplasm StagingOncogene Proteins, FusionOncogenesPrognosisProto-Oncogene Proteins c-retSignal TransductionCirculating Tumor DNAOncogene Proteins, FusionProto-Oncogene Proteins c-retRET protein, human

Identifiers

PMID31300450
PMCPMC6774853
OpenAlexW2961566889

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.