ReviewMolecular metabolism2019
Diet-induced hypothalamic dysfunction and metabolic disease, and the therapeutic potential of polyphenols.
Review in Molecular metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 49 citations in OpenAlex.
- Glucose-lipid metabolic dysregulation and sleep fragmentation in obstructive sleep apnea: insights from a large-scale cross-sectional study and exploratory hypoxia-related single-nucleus transcriptomic analysis.Frontiers in nutrition · 2026Article
- The role of dietary inflammatory index in metabolic diseases: the associations, mechanisms, and treatments.European journal of clinical nutrition · 2025Review
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- Gestational Diabetes and the Gut Microbiota: Fibre and Polyphenol Supplementation as a Therapeutic Strategy.Microorganisms · 2024Review
- Personalizing Nutrition Strategies: Bridging Research and Public Health.Journal of personalized medicine · 2024Review
- Phenolic Profiles, Antihyperglycemic, Anti-Diabetic, and Antioxidant Properties of EgyptianMolecules (Basel, Switzerland) · 2023Article
- Phytochemicals and Vitamin D for a Healthy Life and Prevention of Diseases.International journal of molecular sciences · 2023Review
- Perspectives on Neuronutrition in Prevention and Treatment of Neurological Disorders.Nutrients · 2023Review
- Do Rutin and Quercetin Retain Their Structure and Radical Scavenging Activity after Exposure to Radiation?Molecules (Basel, Switzerland) · 2023Article
- Insulin: A connection between pancreatic β cells and the hypothalamus.World journal of diabetes · 2023Review
- Sterubin protects against chemically-induced Alzheimer's disease by reducing biomarkers of inflammation- IL-6/ IL-β/ TNF-α and oxidative stress- SOD/MDA in rats.Saudi journal of biological sciences · 2023Article
- Effects of a Calorie-Restricted Cafeteria Diet and Oleuropein Supplementation on Adiposity and mRNA Expression of Energy Balance Related Genes in Obese Male Rats.Metabolites · 2023Article
- Hepatic glycogen participates in the regulation of hypothalamic pAkt/Akt ratio in high-sugar/high-fat diet-induced obesity.Metabolic brain disease · 2022Article
- Inflammation in Metabolic and Cardiovascular Disorders-Role of Oxidative Stress.Life (Basel, Switzerland) · 2021Review
- Anti-Obesity Effect of Pine Needle Extract on High-Fat Diet-Induced Obese Mice.Plants (Basel, Switzerland) · 2021Article
- Hypothalamic Inflammation as a Potential Pathophysiologic Basis for the Heterogeneity of Clinical, Hormonal, and Metabolic Presentation in PCOS.Nutrients · 2021Review
- Review
- Sobriety and Satiety: Is NAD+ the Answer?Antioxidants (Basel, Switzerland) · 2020Review
- Review
- PPAR and functional foods: Rationale for natural neurosteroid-based interventions for postpartum depression.Neurobiology of stress · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe prevalence of obesity and metabolic diseases continues to rise globally. The increased consumption of unhealthy energy-rich diets that are high in fat and sugars results in oxidative stress and inflammation leading to hypothalamic dysfunction, which has been linked with these diseases. Conversely, diets rich in polyphenols, which are phytochemicals known for their antioxidant and anti-inflammatory properties, are associated with a reduced risk for developing metabolic diseases. SCOPE OF REVIEW: This review provides an overview of the effects of polyphenols against diet-induced hypothalamic dysfunction with respect to neural inflammation and mitochondrial dysfunction. Results show that polyphenols ameliorate oxidative stress and inflammation within the hypothalamus, thereby improving leptin signaling and mitochondrial biogenesis. Furthermore, they protect against neurodegeneration by decreasing the production of reactive oxygen species and enhancing natural antioxidant defense systems. MAJOR
conclusionsThe potential of polyphenols as nutraceuticals against hypothalamic inflammation, mitochondrial dysfunction, and neurodegeneration could hold tremendous value. With hypothalamic inflammation increasing naturally with age, the potential to modulate these processes in order to extend longevity is exciting and warrants exploration. The continued escalation of mental health disorders, which are characterized by heightened neuronal inflammation, necessitates the furthered investigation into polyphenol therapeutic usage in this regard.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.