Evidence map›Paper›PMID 31300275›Full record

ArticleMolecular cell2019

Structures of the Rhodopsin-Transducin Complex: Insights into G-Protein Activation.

Yang Gao, Hongli Hu, Sekar Ramachandran, Jon W Erickson, Richard A Cerione, Georgios Skiniotis

Open access · greenAbstract read
In one paragraph

Article in Molecular cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
  2. Article
  3. Structure of human green cone opsin yields insights into mechanisms underlying the rapid decay of its active, signaling state.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Optogenetic Control of Dopamine Receptor 2 Reveals a Novel Aspect of Dopaminergic Neurotransmission in Motor Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  8. Article
  9. A rapid, tag-free way to purify functional GPCRs.The Journal of biological chemistry · 2024
    Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Hydration-mediated G-protein-coupled receptor activation.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  17. Review
  18. Review
  19. Universal Properties and Specificities of the βInternational journal of molecular sciences · 2021
    Article
  20. Supramolecular organization of rhodopsin in rod photoreceptor cell membranes.Pflugers Archiv : European journal of physiology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yang GaoDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA.
Hongli HuDepartment of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Sekar RamachandranDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA.
Jon W EricksonDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA.
Richard A CerioneDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA; Department of Molecular Medicine, Cornell University, Ithaca, NY 14853, USA. Electronic address: rac1@cornell.edu.
Georgios SkiniotisDepartment of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: yiorgo@stanford.edu.
Cornell University · USStanford University · US

Funding

Training and OutreachP30GM124166 · NIGMS · CORNELL UNIVERSITY · PI RICHARD A. CERIONE · 2019 to 2026
$28.3M
The unique roles of the GTP-binding/protein crosslinking enzyme transglutaminase-2 and signaling partners in aggressive cancersR01CA201402 · NCI · CORNELL UNIVERSITY · PI CERIONE, RICHARD A. · 2016 to 2024
$4.3M
Structural Basis of Signal Instigation Through Metabotropic Glutamate ReceptorsR01NS092695 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SKINIOTIS, GEORGIOS · 2015 to 2019
$3.4M
New frontiers in extracellular signalingR35GM122575 · NIGMS · CORNELL UNIVERSITY · PI CERIONE, RICHARD A. · 2017 to 2021
$3.0M
NCI NIH HHS R01 CA201402NIGMS NIH HHS P30 GM124166NIGMS NIH HHS R35 GM122575NINDS NIH HHS R01 NS092695
6 · The paper itself

Abstract

Rhodopsin (Rho), a prototypical G-protein-coupled receptor (GPCR) in vertebrate vision, activates the G-protein transducin (G

Indexed as

AnimalsCattleCryoelectron MicroscopyMultiprotein ComplexesProtein DomainsProtein Structure, SecondaryRhodopsinTransducinMultiprotein ComplexesRhodopsinTransducincryo-EMGPCRGPCR-G-protein complexG-proteinphototransductionrhodopsintransducing

Identifiers

PMID31300275
PMCPMC6707884
OpenAlexW2958485150

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.