ReviewSeminars in nephrology2019
Acid Base Balance and Progression of Kidney Disease.
Review in Seminars in nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Article
- Article
- Venous blood gas kinetics and acid-base correction during incremental intermittent hemodialysis in dogs with advanced renal failure.Veterinary world · 2026Article
- Veverimer, a Nonabsorbed Gastrointestinal Tract HCl Binder, Decreases Renal Ammoniagenesis and Mitigates Nephrotoxic Serum Nephritis.Kidney360 · 2025Article
- A Urine pH-Ammonium Acid/Base Score and CKD Progression.Journal of the American Society of Nephrology : JASN · 2024Article
- Metabolic acidosis in chronic kidney disease: mere consequence or also culprit?Pflugers Archiv : European journal of physiology · 2024Review
- Article
- Older patients are less prone to fast decline of renal function: a propensity-matched study.International urology and nephrology · 2023Article
- Metabolic acidosis in pediatric kidney transplant recipients.Pediatric nephrology (Berlin, Germany) · 2023Article
- Oral Acid Load Down-Regulates Fibroblast Growth Factor 23.Nutrients · 2022Article
- Metabolic Acidosis in Chronic Kidney Disease: Pathogenesis, Clinical Consequences, and Treatment.Electrolyte & blood pressure : E & BP · 2021Review
- Low-grade metabolic acidosis as a driver of chronic disease: a 21st century public health crisis.Open heart · 2021Article
- Metabolic Acidosis Is an Independent Risk Factor of Renal Progression in Korean Chronic Kidney Disease Patients: The KNOW-CKD Study Results.Frontiers in medicine · 2021Article
- Veverimer for treatment of chronic metabolic acidosis in patients with chronic kidney disease.Annals of translational medicine · 2020Article
- Evidence for disordered acid-base handling in calcium stone-forming patients.American journal of physiology. Renal physiology · 2020Article
- Advances in management of chronic metabolic acidosis in chronic kidney disease.Current opinion in nephrology and hypertension · 2019Review
- Eubicarbonatemic Hydrogen Ion Retention and CKD Progression.Kidney medicineReview
- Effects of correcting metabolic acidosis in chronic kidney disease patients: An umbrella review.Sage open chronic diseaseReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
A large body of work in animals and human beings supports the hypothesis that metabolic acidosis has a deleterious effect on the progression of kidney disease. Alkali therapy, whether pharmacologically or through dietary intervention, appears to slow CKD progression, but an appropriately powered randomized controlled trial with a low risk of bias is required to reach a more definitive conclusion. Recent work on urinary ammonium excretion has shown that the development of prognostic tools related to acidosis is not straightforward, and that application of urine markers such as ammonium may require more nuance than would be predicted based on our understanding of the pathophysiology.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.