Evidence map›Paper›PMID 31300094›Full record

ReviewSeminars in nephrology2019

Emerging Features of Ammonia Metabolism and Transport in Acid-Base Balance.

I David Weiner, Jill W Verlander

Open access · greenAbstract readReview
In one paragraph

Review in Seminars in nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Role of KThe American journal of pathology · 2025
    Article
  6. Article
  7. Review
  8. Chloride Gradient Is Involved in Ammonium Influx in Human Erythrocytes.International journal of molecular sciences · 2024
    Article
  9. State of knowledge on ammonia handling by the kidney.Pflugers Archiv : European journal of physiology · 2024
    Review
  10. Review
  11. Review
  12. Circadian gene expression in mouse renal proximal tubule.American journal of physiology. Renal physiology · 2023
    Article
  13. Article
  14. Article
  15. Control of sodium and potassium homeostasis by renal distal convoluted tubules.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2023
    Article
  16. Article
  17. Article
  18. Acid-base effects of combined renal deletion of NBCe1-A and NBCe1-B.American journal of physiology. Renal physiology · 2022
    Article
  19. Review
  20. Role of the renal androgen receptor in sex differences in ammonia metabolism.American journal of physiology. Renal physiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

I David WeinerDivision of Nephrology, Hypertension and Renal Transplantation, University of Florida College of Medicine, Gainesville, FL; Nephrology and Hypertension Section, Gainesville Veterans Affairs Medical Center, Gainesville, FL. Electronic address: david.weiner@medicine.ufl.edu.
Jill W VerlanderDivision of Nephrology, Hypertension and Renal Transplantation, University of Florida College of Medicine, Gainesville, FL.
Florida College · US

Funding

H/HCO3 transport in the collecting ductR01DK045788 · NIDDK · UNIVERSITY OF FLORIDA · PI WEINER, I. DAVID · 2000 to 2017
$4.4M
Molecular Mechanisms Regulating Ammonia MetabolismR01DK107798 · NIDDK · UNIVERSITY OF FLORIDA · PI WEINER, I. DAVID · 2016 to 2025
$3.2M
NIDDK NIH HHS R01 DK045788NIDDK NIH HHS R01 DK107798
6 · The paper itself

Abstract

Ammonia metabolism has a critical role in acid-base homeostasis and in other cellular functions. Kidneys have a central role in bicarbonate generation, which occurs through the process of net acid excretion; ammonia metabolism is the quantitatively greatest component of net acid excretion, both under basal conditions and in response to acid-base disturbances. Several recent studies have advanced our understanding substantially of the molecular mechanisms and regulation of ammonia metabolism. First, the previous paradigm that ammonia transport could be explained by passive NH

Indexed as

Acid-Base EquilibriumAcidosisAmmoniaAnimalsBiological TransportHomeostasisHumansHyperkalemiaKidneyAmmoniaAmmoniachronic kidney diseaseglutamine synthetasehepatic encephalopathylithiumNBCe1

Identifiers

PMID31300094
PMCPMC6629433
OpenAlexW2956683312

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.