Evidence map›Paper›PMID 31300057›Full record

ArticleParticle and fibre toxicology2019

Iron oxide nanoparticles induce reversible endothelial-to-mesenchymal transition in vascular endothelial cells at acutely non-cytotoxic concentrations.

Tao Wen, Lifan Du, Bo Chen, Doudou Yan, Aiyun Yang, Jian Liu, Ning Gu, Jie Meng, Haiyan Xu

Open access · goldAbstract read
In one paragraph

Article in Particle and fibre toxicology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Iron metabolism in rheumatic diseases.Journal of translational autoimmunity · 2025
    Review
  8. Article
  9. Magneto-Mechanical Actuation Induces Endothelial Permeability.ACS biomaterials science & engineering · 2023
    Article
  10. Article
  11. Article
  12. Article
  13. Role of Iron Oxide (FeNanomaterials (Basel, Switzerland) · 2022
    Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Tao WenInstitute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China.
Lifan DuInstitute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China.
Bo ChenMaterials Science and Devices Institute, Suzhou University of science and Technology, Suzhou, 215009, China.
Doudou YanInstitute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China.
Aiyun YangInstitute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China.
Jian LiuInstitute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China.
Ning GuState Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.
Jie MengInstitute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China. mengjie@ibms.pumc.edu.cn.
Haiyan XuInstitute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China. xuhy@pumc.edu.cn.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNState Key Laboratory of Digital Medical EngineeringSuzhou University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIron oxide nanoparticles (IONPs) have been extensively studied in different biomedical fields. Recently, the non-cytotoxic concentration of IONPs induced cell-specific response raised concern of their safety. Endothelial cell exposure was unavoidable in their applications, while whether IONPs affect the phenotype of vascular endothelial cells is largely unknown. In this work, the effect of IONPs on endothelial-to-mesenchymal transition (EndMT) was investigated in vitro and in vivo.

resultsThe incubation with γ-Fe

conclusionThe PSC-Fe

Indexed as

ActinsAntigens, CDCadherin 5CadherinsCell SurvivalDose-Response Relationship, DrugEpithelial-Mesenchymal TransitionFerric CompoundsGene ExpressionHumansHuman Umbilical Vein Endothelial CellsNanoparticlesPlatelet Endothelial Cell Adhesion Molecule-1ACTA2 protein, humanActinsAntigens, CDCadherin 5CadherinsFerric Compoundsferric oxidePECAM1 protein, humanPlatelet Endothelial Cell Adhesion Molecule-1Endothelial-to-mesenchymal transitionIron oxide nanoparticleReactive oxygen speciesReversible

Identifiers

PMID31300057
PMCPMC6626375
OpenAlexW2962192295

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.