Evidence map›Paper›PMID 31300028›Full record

ArticleTrials2019

Implementation and effectiveness of evriMED with short messages service (SMS) reminders and tailored feedback compared to standard care on adherence to treatment among tuberculosis patients in Kilimanjaro, Tanzania: proposal for a cluster randomized controlled trial.

Marion Sumari-de Boer, Francis M Pima, Kennedy M Ngowi, Geoffrey M Chelangwa, Benson A Mtesha, Linda M Minja, Hadija H Semvua, Stella Mpagama, Blandina T Mmbaga, Pythia T Nieuwkerk and 1 more

Abstract readClinical Trial Protocol
In one paragraph

Article in Trials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Marion Sumari-de BoerKilimanjaro Clinical Research Institute (KCRI), PO Box 2236, Moshi, Tanzania. m.sumari@kcri.ac.tz.
Francis M PimaKilimanjaro Clinical Research Institute (KCRI), PO Box 2236, Moshi, Tanzania.
Kennedy M NgowiKilimanjaro Clinical Research Institute (KCRI), PO Box 2236, Moshi, Tanzania.
Geoffrey M ChelangwaNational Tuberculosis and Leprosy Programme, Dar es Salaam, Tanzania.
Benson A MteshaKilimanjaro Clinical Research Institute (KCRI), PO Box 2236, Moshi, Tanzania.
Linda M MinjaKilimanjaro Clinical Research Institute (KCRI), PO Box 2236, Moshi, Tanzania.
Hadija H SemvuaKilimanjaro Clinical Research Institute (KCRI), PO Box 2236, Moshi, Tanzania.
Stella MpagamaKibong'oto Infectious Diseases Hospital, Sanya Juu, Tanzania.
Blandina T MmbagaKilimanjaro Clinical Research Institute (KCRI), PO Box 2236, Moshi, Tanzania.
Pythia T NieuwkerkDepartment of Medical Psychology, Amsterdam UMC, Amsterdam, the Netherlands.
Rob E AarnoutseDepartment of Clinical Pharmacology, RadboudUMC, Nijmegen, the Netherlands.

Funding

Stop TB partnership 1169
6 · The paper itself

Abstract

backgroundAdherence to tuberculosis (TB) treatment is challenging because of many factors. The World Health Organization has recommended the use of digital adherence monitoring technologies in its End TB Strategy. However, evidence on improving adherence is limited. EvriMED is a real-time medication-monitoring device which was found to be feasible and acceptable in a few studies in Asia. In Tanzania, however, there may be challenges in implementing evriMED due to stigmatization, network and power access, accuracy, and cost effectiveness, which may have implications for treatment outcome. We propose a pragmatic cluster randomized trial to investigate the effectiveness of evriMED with reminder cues and tailored feedback on adherence to TB treatment in Kilimanjaro, Tanzania. METHODS/

designWe will create clusters in Kilimanjaro based on level of health care facility. Clusters will be randomized in an intervention arm, where evriMED will be implemented, or a control arm, where standard practice directly observed treatment will be followed. TB patients in intervention clusters will take their medication from the evriMED pillbox and receive tailored feedback. We will use the 'Stages of Change' model, which assumes that a person has to go through the stages of pre-contemplation, contemplation, preparation, action, and evaluation to change behavior for tailored feedback on adherence reports from the device. DISCUSSION: If the intervention shows a significant effect on adherence and the devices are accepted, accurate, and sustainable, the intervention can be scaled up within the National Tuberculosis Programmes.

trial registrationPan African Clinical Trials Registry, PACTR201811755733759 . Registered on 8 November 2018.

Indexed as

Feedback, PsychologicalMedication AdherenceReminder SystemsText MessagingAdolescentAdultAgedAntitubercular AgentsCuesFemaleHealth Knowledge, Attitudes, PracticeHumansMaleMiddle AgedMulticenter Studies as TopicPragmatic Clinical Trials as TopicAntitubercular AgentsAdherenceCluster randomized trialevriMEDmHealthReal-time medication monitoringResource-limited settingTuberculosis

Identifiers

PMID31300028
PMCPMC6626331

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.