Evidence map›Paper›PMID 31299955›Full record

SynthesisBMC oral health2019

Silver diamine fluoride for managing carious lesions: an umbrella review.

Nassar Seifo, Heather Cassie, John R Radford, Nicola P T Innes

3 registry-linked trialsOpen access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC oral health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 93 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 6 pooled it
17.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04255251 early_phase1unknown statusnot on this mapstarted 2021, after this paper: background citation

Effectiveness Silver Diamine Fluoride Versus Sodium Fluoride in Arresting Caries Around Crown Margins in Older Adults

TypeinterventionalSponsorUniversity of New EnglandRan2021 to 2024Enrolled200ConditionsCaries Roots, Flouride Varnish, Caries, DentinArmsSilver Diammine Fluoride, Fluoride Varnishes
NCT07194629 phase4not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Impact of Silver Diamine Fluoride (SDF) 38% Application on the Oral Health of the Elderly With Loss of Autonomy Living in Long-term Care Homes (CHSLDs): A Pilot and Feasibility Effectiveness Study

TypeinterventionalSponsorUniversité de MontréalRan2025 to 2026Enrolled60ConditionsDental Caries, Elderly, Loss of Autonomy, Silver Diamine FluorideArmsSilver diamine Fluoride 38%, placebo solution
NCT07447583 nacompletednot on this mapstarted 2024, after this paper: background citation

An 18-Month Split-Mouth Randomized Clinical Trial Comparing the Hall Technique, Silver Diamine Fluoride, and Compomer Restorations for the Management of Caries in Primary Molars in Children Aged 4-8 Years

TypeinterventionalSponsorTC Erciyes UniversityRan2024 to 2026Enrolled60ConditionsDental CariesArmsHall Technique, Silver diamine Fluoride 38%, Compomer Restoration
3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 6 syntheses or guidelines pooled it, 213 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Trial
  18. Is Silver Diamine Fluoride Effective in Arresting Enamel Caries? A Randomized Clinical Trial.International journal of environmental research and public health · 2022
    Trial
  19. Trial
  20. Article

33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Nassar SeifoSchool of Dentistry, University of Dundee, Park Place, Dundee, DD1 4HR, UK.
Heather CassieSchool of Dentistry, University of Dundee, Park Place, Dundee, DD1 4HR, UK.
John R RadfordSchool of Dentistry, University of Dundee, Park Place, Dundee, DD1 4HR, UK.
Nicola P T InnesSchool of Dentistry, University of Dundee, Park Place, Dundee, DD1 4HR, UK. n.p.innes@dundee.ac.uk.ORCID 0000-0002-9984-0012
University of Dundee · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis umbrella review comprehensively appraised evidence for silver diamine fluoride (SDF) to arrest and prevent root and coronal caries by summarizing systematic reviews. Adverse events were explored.

methodsFollowing Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines, PubMed, Embase, Cochrane Library, PROSPERO register and Joanna Briggs Institute Database of Systematic Reviews were searched for systematic reviews investigating SDF for caries prevention or arrest (1970-2018) without language restrictions. Systematic reviews were selected, data extracted, and risk of bias assessed using ROBIS by two independent reviewers, in duplicate. Corrected covered area was calculated to quantify studies' overlap across reviews.

resultsEleven systematic reviews were included; four focussing on SDF for root caries in adults and seven on coronal caries in children. These cited 30 studies (4 root caries; 26 coronal caries) appearing 63 times. Five systematic reviews were of "low", one "unclear" and five "high" risk of bias. Overlap of studies was very high (50% root caries; 17% coronal caries). High overlap and heterogeneity, mainly comparators and outcome measures, precluded meta-analysis. Results were grouped by aim and outcomes to present an overview of direction and magnitude of effect. SDF had a positive effect on prevention and arrest of coronal and root caries, consistently outperforming comparators (fluoride varnish, Atraumatic Restorative Treatment, placebo). For root caries prevention, the prevented fraction (PF) was 25-71% higher for SDF compared to placebo (two systematic reviews with three studies) and PF = 100-725% for root caries arrest (one systematic review with two studies). For coronal caries prevention, PF = 70-78% (two systematic reviews with two studies) and PF = 55-96% for coronal caries arrest (one systematic review with two studies) with arrest rates of 65-91% (four systematic reviews with six studies). Eight systematic reviews reported adverse events, seven of which reported arrested lesions black staining.

conclusionSystematic reviews consistently supported SDF's effectiveness for arresting coronal caries in the primary dentition and arresting and preventing root caries in older adults for all comparators. There is insufficient evidence to draw conclusions on SDF for prevention in primary teeth and prevention and arrest in permanent teeth in children. No serious adverse events were reported.

Indexed as

Dental Atraumatic Restorative TreatmentDental CariesQuaternary Ammonium CompoundsSilver CompoundsAgedCariostatic AgentsChildFluorides, TopicalHumansCariostatic AgentsFluorides, TopicalQuaternary Ammonium CompoundsSilver Compoundssilver diamine fluorideOverviewSilver diamine fluorideSystematic reviewUmbrella review

Identifiers

PMID31299955
PMCPMC6626340
OpenAlexW2960697937

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.