Evidence map›Paper›PMID 31299945›Full record

ArticleBMC musculoskeletal disorders2019

The efficacy and safety of tranexamic acid for reducing blood loss following simultaneous bilateral total knee arthroplasty: a multicenter retrospective study.

Guorui Cao, Guo Chen, Qiang Huang, Zeyu Huang, Peter G Alexander, Hang Lin, Hong Xu, Zongke Zhou, Fuxing Pei

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC musculoskeletal disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Trial
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  4. Observational
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  8. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Guorui CaoDepartment of Orthopaedic surgery, West China Medical School, West China Hospital, Sichuan University, 37# Guoxue Road, Chengdu, Sichuan Province, 610041, People's Republic of China.
Guo ChenDepartment of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong Province, People's Republic of China.
Qiang HuangDepartment of Orthopaedic surgery, West China Medical School, West China Hospital, Sichuan University, 37# Guoxue Road, Chengdu, Sichuan Province, 610041, People's Republic of China.
Zeyu HuangDepartment of Orthopaedic surgery, West China Medical School, West China Hospital, Sichuan University, 37# Guoxue Road, Chengdu, Sichuan Province, 610041, People's Republic of China.
Peter G AlexanderCenter for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, USA.
Hang LinCenter for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, USA.
Hong XuDepartment of Orthopaedic surgery, West China Medical School, West China Hospital, Sichuan University, 37# Guoxue Road, Chengdu, Sichuan Province, 610041, People's Republic of China.
Zongke ZhouDepartment of Orthopaedic surgery, West China Medical School, West China Hospital, Sichuan University, 37# Guoxue Road, Chengdu, Sichuan Province, 610041, People's Republic of China.
Fuxing PeiDepartment of Orthopaedic surgery, West China Medical School, West China Hospital, Sichuan University, 37# Guoxue Road, Chengdu, Sichuan Province, 610041, People's Republic of China. peifuxingwestchina@yeah.com.ORCID http://orcid.org/0000-0003-3736-4724

Funding

Safety and effect evaluation of joint replacement 201302007
6 · The paper itself

Abstract

backgroundThe purpose of the study was to evaluate whether tranexamic acid (TXA) administration could reduce blood loss and transfusion risk after simultaneous bilateral total knee arthroplasty (SBTKA).

methodsAs a multicenter retrospective study, a total of 575 patients were assigned into three groups on the basis of TXA usage, including intravenous (IV) group (1 g IV TXA 5-10 min prior to the incision), combined group (1 g IV TXA combined with intra-articular injection of 1 g TXA prior to the closure every knee) and control group (no TXA use). The primary outcomes were total blood loss (TBL). The secondary outcomes were maximum hemoglobin (Hb) and hematocrit (Hct) drop, transfusion rate, drain volume, length of stay, hospitalization expenses and the incidence of complications.

resultsThe mean TBL in control group (1685.0 ± 571.4 mL) were higher than that in IV group (1061.1 ± 689.6 mL, p = 0.006 and combined group (988.3 ± 559.3 mL, p = 0.003). The maximum Hb and Hct drop in combined group (28.5 ± 13.4 g/L, p = 0.016; 0.074 ± 0.053, p < 0.001) and IV group (28.8 ± 14.5 g/L, p = 0.025; 0.082 ± 0.056, p = 0.001) were lower than those in control group (33.4 ± 14.0; 0.131 ± 0.049). But the difference between IV and combined groups was not significant. The similar trend was detected on drain volume, length of stay and hospitalization expenses. The incidence of complications did not differ significantly among the three groups (p > 0.05).

conclusionsThe study indicates that TXA could reduce blood loss with no apparent increase in the incidence of complications during SBTKA.

Indexed as

Administration, IntravenousAgedAntifibrinolytic AgentsArthroplasty, Replacement, KneeBlood Loss, SurgicalBlood TransfusionFemaleHematocritHemoglobinsHumansIncidenceInjections, Intra-ArticularLength of StayMaleMiddle AgedOsteoarthritis, KneeAntifibrinolytic AgentsHemoglobinsTranexamic AcidBlood lossSimultaneous bilateralTotal knee arthroplastyTranexamic acidTransfusion

Identifiers

PMID31299945
PMCPMC6626401

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.