ArticleBMC cancer2019
Sexual dimorphism in the incidence of human cancers.
Article in BMC cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sex/gender differences in the association between behavioural factors and cancers: an umbrella review of systematic reviews with quantitative synthesis.Biology of sex differences · 2025Pooled it
- Disparities in Cancer Incidence by Sex and Associated Lifestyle Factors and Health Conditions.JAMA oncology · 2026Article
- Fairness-aware supervised hierarchical contrastive semantic learning for sexual dimorphism analysis.Bioinformatics (Oxford, England) · 2026Article
- Radiation as an immune modulator: mechanisms and implications for combination with immunotherapy.Nature reviews. Cancer · 2026Review
- Contribution of Sex-Biased Expressed Genes in Osteoarthritis.Smart medicine · 2025Article
- Sex differences in cancer incidence: prospective analyses in the UK Biobank.British journal of cancer · 2025Article
- Mimicking women's endocrine milieu in mice for women's health-related studies.npj women's health · 2025Article
- Y Chromosome Loss and Implications for Oncology.Molecular cancer research : MCR · 2024Review
- SPIN: sex-specific and pathway-based interpretable neural network for sexual dimorphism analysis.Briefings in bioinformatics · 2024Article
- Sex differences in colonic gene expression and fecal microbiota composition in a mouse model of obesity-associated colorectal cancer.Scientific reports · 2024Article
- Role of sex steroids in colorectal cancer: pathomechanisms and medical applications.American journal of cancer research · 2024Review
- Review
- Deficiency of histone variant macroH2A1.1 is associated with sexually dimorphic obesity in mice.Scientific reports · 2023Article
- Article
- Integrative analysis of histone acetyltransferase KAT2A in human cancer.Cancer biomarkers : section A of Disease markers · 2023Article
- Sex differences in brain tumor glutamine metabolism reveal sex-specific vulnerabilities to treatment.Med (New York, N.Y.) · 2022Article
- Sex-specific familial aggregation of cancers in Finland.Scientific reports · 2022Article
- Age influences on the molecular presentation of tumours.Nature communications · 2022Article
- SDC: An integrated database for sex differences in cancer.Computational and structural biotechnology journal · 2022Article
- Papillary Thyroid Cancer Prognosis: An Evolving Field.Cancers · 2021Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundSex differences in the incidences of cancers become a critical issue in both cancer research and the development of precision medicine. However, details in these differences have not been well reported. We provide a comprehensive analysis of sexual dimorphism in human cancers.
methodsWe analyzed four sets of cancer incidence data from the SEER (USA, 1975-2015), from the Cancer Registry at Mayo Clinic (1970-2015), from Sweden (1970-2015), and from the World Cancer Report in 2012.
resultsWe found that all human cancers had statistically significant sexual dimorphism with male dominance in the United States and mostly significant in the Mayo Clinic, Sweden, and the world data, except for thyroid cancer, which is female-dominant.
conclusionsSexual dimorphism is a clear but mostly neglected phenotype for most human cancers regarding the clinical practice of cancer. We expect that our study will facilitate the mechanistic studies of sexual dimorphism in human cancers. We believe that fully addressing the mechanisms of sexual dimorphism in human cancers will greatly benefit current development of individualized precision medicine beginning from the sex-specific diagnosis, prognosis, and treatment.
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