ArticleBMC nephrology2019
Moderately increased albuminuria, chronic kidney disease and incident dementia: the HUNT study.
Article in BMC nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- The association between cognitive impairment/dementia and albuminuria: a systematic review and meta-analysis.Clinical and experimental nephrology · 2022Pooled it
- Albuminuria is associated with increased risk of dementia, independent of eGFR: The SCREAM project.Journal of internal medicine · 2025Article
- Kidney Function, Cognitive Impairment, and Trajectories: A Longitudinal Biracial Study.Journal of general internal medicine · 2025Article
- Crosstalk of kidney and brain in diabetes-related cognitive impairment and therapeutic strategies.Frontiers in endocrinology · 2025Review
- Mid- and Late-Life Chronic Kidney Disease Is Associated with Parkinson's Disease, Not with an Increased Risk of Alzheimer's Disease.Journal of personalized medicine · 2024Article
- Association of Kidney Function With Dementia and Structural Brain Differences: A Large Population-Based Cohort Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Relationship between chronic kidney disease and cerebral white matter hyperintensities: a systematic review.Quantitative imaging in medicine and surgery · 2023Review
- Kidney function, albuminuria, and their modification by genetic factors and risk of incident dementia in UK Biobank.Alzheimer's research & therapy · 2023Article
- Exploring the Link between Chronic Kidney Disease and Alzheimer's Disease: A Longitudinal Follow-Up Study Using the Korean National Health Screening Cohort.Biomedicines · 2023Article
- Risk of New-Onset Dementia in Patients with Chronic Kidney Disease on Statin Users: A Population-Based Cohort Study.Biomedicines · 2023Article
- CKD Progression Risk and Subsequent Cause of Death: A Population-Based Cohort Study.Kidney medicine · 2023Article
- Association of Kidney Function With Development of Alzheimer Disease and Other Dementias and Dementia-Related Blood Biomarkers.JAMA network open · 2023Article
- Albuminuria, cognition, and MRI biomarkers of cerebrovascular disease in American Indians of the Zuni Pueblo.eNeurologicalSci · 2022Article
- Mild to moderate decrease in eGFR and cognitive decline in older adults.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2022Article
- Markers of kidney function, genetic variation related to cognitive function, and cognitive performance in the UK Biobank.BMC nephrology · 2022Article
- Insights into Cognitive Brain Health in Chronic Kidney Disease.Gerontology & geriatrics : research · 2022Article
- Article
- Albuminuria as a risk factor for mild cognitive impairment and dementia-what is the evidence?Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2021Review
- Article
- Diabetes, Albuminuria and the Kidney-Brain Axis.Journal of clinical medicine · 2021Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEpidemiologic studies has shown an association of albuminuria and low estimated glomerular filtration rate (eGFR) with dementia, but the findings are inconsistent. This study examines the association between eGFR, MA with dementia and its subtypes: AD, VaD, a mixture of AD/VaD, and other dementias.
methodsData from the second wave of the HUNT 2 Study (1995-1997) were linked with a dementia register known as the Health and Memory Study (HMS) collected during 1995-2011 in Nord-Trøndelag County, Norway. Dementia was ascertained using World Health Organization's ICD-10 criteria into subtypes: AD,VaD, mixed AD/VaD, and other dementia. eGFR and its association with dementia was examined in 48,508 participants of the HUNT Study, of which 668 were diagnosed with all-cause dementia. Association between MA and dementia were studied in a subset of 7024 participants, and 214 were diagnosed with all-cause dementia. Cox regression models were conducted analyzing the association between dementia and MA using albumin creatine ratio (ACR). Cox regression models and Fine-Gray models were used to examine the association between dementia and eGFR.
resultsA positive association was found between increasing ACR and dementia. ACR in the fourth quartile (> 1.78 mg/mmol) with increased hazard ratio of VaD, 3.97 (1.12 to 14.07), compared with ACR in the first quartile (<.53 mg/mmol). There was no association between eGFR and dementia or its subgroups.
conclusionsOur results strengthens the hypothesis that vascular mechanisms may affect both kidney and brain as an association between MA and dementia was found. However, eGFR was not significantly associated with dementia independent of diabetes mellitus or hypertension.
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