Evidence map›Paper›PMID 31299920›Full record

ArticleBMC cancer2019

Measuring the impact of oesophagectomy on physical functioning and physical activity participation: a prospective study.

E M Guinan, A E Bennett, S L Doyle, L O'Neill, J Gannon, G Foley, J A Elliott, J O'Sullivan, J V Reynolds, J Hussey

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 31 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05035602 completednot on this mapstarted 2022, after this paper: background citation

Google Location History (GLH) as a Health Tool to Assess Physical Activity Profiles and Patterns Following Oesophagectomy and/or Gastrectomy

TypeobservationalSponsorImperial College LondonRan2022 to 2023Enrolled3ConditionsOesophageal Cancer, Gastric Cancer, Survivorship, Quality of LifeArmsPhysical activity assessment
NCT07691944 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Effect of VExUS Score-Guided Intraoperative Goal-Directed Fluid Therapy on Postoperative Pulmonary Complications in Elderly Patients Undergoing McKeown Minimally Invasive Esophagectomy: A Randomized Controlled Trial

TypeobservationalSponsorFirst Affiliated Hospital of Chongqing Medical UniversityRan2026 to 2026Enrolled126ConditionsEsophageal Cancer (EsC), Postoperative Pulmonary Complications (PPCs)ArmsVExUS Score-Guided Intraoperative Goal-Directed Fluid Therapy
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Trial
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  8. Observational
  9. Review
  10. Article
  11. Changes in Components of Sarcopenia Diagnostic Criteria Throughout the Surgical Treatment of Oesophagogastric Cancer Surgery: A Prospective Longitudinal Study.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2026
    Observational
  12. Observational
  13. Article
  14. The prevalence, nature and severity of oropharyngeal dysphagia in the acute post-operative phase following curative resection for esophageal cancer.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2025
    Article
  15. Factors associated with functional ability in patients with esophageal cancer undergoing chemoradiotherapy: a prospective longitudinal study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Article
  16. Article
  17. The impact of endoscopic treatment on health-related quality of life in patients with Barrett's neoplasia: a scoping review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024
    Article
  18. Measurement and optimization of perioperative risk among patients undergoing surgery for esophageal cancer.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

E M GuinanSchool of Medicine, Trinity College Dublin, Dublin, Ireland. emguinan@tcd.ie.ORCID http://orcid.org/0000-0001-9715-146X
A E BennettDepartment of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin, Ireland.
S L DoyleSchool of Biological Sciences, Dublin Institute of Technology, Dublin, Ireland.
L O'NeillDiscipline of Physiotherapy, School of Medicine, Trinity College Dublin, Dublin, Ireland.
J GannonDiscipline of Physiotherapy, School of Medicine, Trinity College Dublin, Dublin, Ireland.
G FoleyDiscipline of Physiotherapy, School of Medicine, Trinity College Dublin, Dublin, Ireland.
J A ElliottDepartment of Surgery, St. James' Hospital, Dublin, Ireland.
J O'SullivanTrinity Translational Medicine Institute, Department of Surgery, Trinity College Dublin, Dublin, Ireland.
J V ReynoldsDepartment of Surgery, St. James' Hospital, Dublin, Ireland.
J HusseyDiscipline of Physiotherapy, School of Medicine, Trinity College Dublin, Dublin, Ireland.

Funding

Health Research Board POR HRA-POR-2014-535Wellcome Trust
6 · The paper itself

Abstract

backgroundOesophagectomy remains the only curative intervention for oesophageal cancer, with defined nutritional and health-related quality of life (HR-QOL) consequences. It follows therefore that there is a significant risk of decline in physical wellbeing with oesophagectomy however this has been inadequately quantified. This study prospectively examines change in physical functioning and habitual physical activity participation, from pre-surgery through 6-months post-oesophagectomy.

methodsPatients scheduled for oesophagectomy with curative intent were recruited. Key domains of physical functioning including exercise tolerance (six-minute walk test (6MWT)) and muscle strength (hand-grip strength), and habitual physical activity participation, including sedentary behaviour (accelerometry) were measured pre-surgery (T0) and repeated at 1-month (T1) and 6-months (T2) post-surgery. HR-QOL was measured using the EORTC-QOL C30.

resultsThirty-six participants were studied (mean age 62.4 (8.8) years, n = 26 male, n = 26 transthoracic oesophagectomy). Mean 6MWT distance decreased significantly from T0 to T1 (p = 0.006) and returned to T0 levels between T1 and T2 (p < 0.001). Percentage time spent sedentary increased throughout recovery (p < 0.001) and remained significantly higher at T2 in comparison to T0 (p = 0.003). In contrast, percentage time spent engaged in either light or moderate-to-vigorous intensity activity, all reduced significantly (p < 0.001 for both) and remained significantly lower at T2 in comparison to T0 (p = 0.009 and p = 0.01 respectively). Patients reported deficits in multiple domains of HR-QOL during recovery including global health status (p = 0.04), physical functioning (p < 0.001) and role functioning (p < 0.001). Role functioning remained a clinically important 33-points lower than pre-operative values at T2.

conclusionHabitual physical activity participation remains significantly impaired at 6-months post-oesophagectomy. Physical activity is a measurable and modifiable target for physical rehabilitation, which is closely aligned with patient-reported deficits in role functioning. Rehabilitation aimed at optimising physical health in oesophageal cancer survivorship is warranted.

Indexed as

ExerciseHealth StatusAdultAgedCancer SurvivorsEsophageal NeoplasmsEsophagectomyFemaleHumansMaleMiddle AgedProspective StudiesPublic Health SurveillanceQuality of LifeRisk FactorsHealth-related quality of lifeOesophageal cancerPhysical activityPhysical functioningSurvivorship care

Identifiers

PMID31299920
PMCPMC6624943

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.