ArticleBMC infectious diseases2019
Phylogeny, sequence-typing and virulence profile of uropathogenic Escherichia coli (UPEC) strains from Pakistan.
Article in BMC infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 42 citations in OpenAlex.
- Insights into the phylogenetic profile and virulence-associated genes of multidrug-resistant uropathogenicIJID regions · 2025Article
- Pathogenesis and Immunomodulation of Urinary Tract Infections Caused by UropathogenicMicroorganisms · 2025Review
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- Analysis ofFrontiers in cellular and infection microbiology · 2024Article
- Phylogenetic group, antibiotic resistance, virulence gene, and genetic diversity ofFrontiers in microbiology · 2024Article
- Genomic characterization of a multidrug-resistant uropathogenicAIMS microbiology · 2024Article
- Moving microcapillary antibiotic susceptibility testing (mcAST) towards the clinic: unravelling kinetics of detection of uropathogenicSensors & diagnostics · 2023Article
- The genotypic and phenotypic characteristics contributing to high virulence and antibiotics resistance in Escherichia coli O25-B2-ST131 in comparison to non- O25-B2-ST131.BMC pediatrics · 2023Article
- Synergistic Effects of Gentamicin, Cefepime, and Ciprofloxacin on Biofilm ofInfection and drug resistance · 2023Article
- Investigating the Role of Antibiotics on Induction, Inhibition and Eradication of Biofilms of Poultry AssociatedAntibiotics (Basel, Switzerland) · 2022Article
- Pathogenicity Islands in UropathogenicAntibiotics (Basel, Switzerland) · 2022Article
- Possible step-up in prevalence for Escherichia coli ST131 from fecal to clinical isolates: inferred virulence potential comparative studies within phylogenetic group B2.Journal of biomedical science · 2022Article
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- High Genetic Diversity and Antimicrobial Resistance inMicroorganisms · 2022Article
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- Virulence Genes Profile and Antimicrobial Susceptibility of Community-Acquired Bacterial Urinary Tract Infections in a Brazilian Hospital.Current microbiology · 2021Article
- Virulence genes and phylogenetic groups of uropathogenic Escherichia coli isolates from patients with urinary tract infection and uninfected control subjects: a case-control study.BMC infectious diseases · 2021Article
- Comparative Study of CTX-M-15 ProducingInfection and drug resistance · 2021Article
- Frequency of hlyA, hlyB, hlyC and hlyD genes in uropathogenic Escherichia coli isolated from UTI patients in Shiraz.GMS hygiene and infection control · 2021Article
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8 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundEscherichia coli lineage ST131 predominates across various spectra of extra-intestinal infections, including urinary tract infection (UTI). The distinctive resistance profile, diverse armamentarium of virulence factors and rapid global dissemination of ST131 E. coli makes it an intriguing pathogen. However, not much is known about the prevalence and genetic attributes of ST131 lineage in Pakistan.
methodsWe estimated prevalence and genetic attributes of E. coli ST131 isolates causing UTI among 155 randomly selected samples. Samples were analyzed for phylogenetic grouping, O-typing and fumC/fimH typing. Isolates were further tested for the ESBL and virulence factors using PCR.
resultsOverall, 59% of the UPEC isolates belonged to the phylogenetic group B2, followed by D = 28%, B1 = 8% and A = 5%. Among 18 different Sequence-types, ST131 was the dominant lineage (n = 71; 46%) out of which 72% of the isolates were assigned to the phylogenetic group B2, while 61% adhered to the serogroup O25b. FumC/fimH typing confirmed 49% of the ST131 as H30 sub-types. In this study, significant numbers of the identified ST131 isolates were MDR and 42% showed ESBL phenotypes, out of which 37% carried bla-
conclusionConclusively, this study provides important insight into the genetic and virulence attributes of pandemic MDR ST131 strains involved in UTIs. It also highlights higher prevalence of ST131-O25b-H30 UPEC isolates in patients, which was previously unreported from this part of globe.
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