ArticleBMC plant biology2019
Tracing the origin and evolution history of methylation-related genes in plants.
Article in BMC plant biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 99 citations in OpenAlex.
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- Characterization and differential expression of DNA methyltransferase and demethylase genes in response to abiotic stress in Isodon rubescens.BMC plant biology · 2025Article
- Phylogenomic analysis reveals exceptions to the co-evolution of ZAR1 and ZRK immune gene families in plants.BMC plant biology · 2025Article
- Origin, Evolution, and Diversification of the Expansin Family in Plants.International journal of molecular sciences · 2024Article
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- Somatic DNA demethylation generates tissue-specific methylation states and impacts flowering time.The Plant cell · 2022Article
- Exploring Breakthroughs in Three Traits Belonging to Seed Life.Plants (Basel, Switzerland) · 2022Review
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- The epigenetic origin of life history transitions in plants and algae.Plant reproduction · 2021Review
- Evolution of CG Methylation Maintenance Machinery in Plants.Epigenomes · 2021Review
- Genome-wide identification and analysis of DNA methyltransferase and demethylase gene families in Dendrobium officinale reveal their potential functions in polysaccharide accumulation.BMC plant biology · 2021Article
- Application of the MSAP Technique to Evaluate Epigenetic Changes in Plant Conservation.International journal of molecular sciences · 2020Review
- RNA directed DNA methylation and seed plant genome evolution.Plant cell reports · 2020Review
- Modification of Experimental Design and Statistical Method for Mapping Imprinted QTLs Based on Immortalized FFrontiers in genetics · 2020Article
- DNA Methylation Silences Exogenous Gene Expression in Transgenic Birch Progeny.Frontiers in plant science · 2020Article
- Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundDNA methylation is a crucial epigenetic modification, which is involved in many biological processes, including gene expression regulation, embryonic development, cell differentiation and genomic imprinting etc. And it also involves many key regulatory genes in eukaryotes. By tracing the evolutionary history of methylation-related genes, we can understand the origin and expansion time of these genes, which helps to understand the evolutionary history of plants, and we can also understand the changes of DNA methylation patterns in different species. However, most studies on the evolution of methylation-related genes failed to be carried out for the whole DNA methylation pathway.
resultsIn this study, we conducted a comprehensive identification of 33 methylation-related genes in 77 species, and investigated gene origin and evolution throughout the plant kingdom. We found that the origin of genes responsible for methylation maintenance and demethylation evolved early, while most de novo methylation-related genes appeared late. The methylation-related genes were expanded by whole genome duplication and tandem replication, but were also accompanied by a large number of gene absence events in different species. The gene length and intron length varied a lot in different species, but exon structure and functional domains were relatively conserved. The phylogenetic relationships of methylation-related genes were traced to reveal the evolution history of DNA methylation in different species. The expression patterns of methylation-related genes have changed during the evolution of species, and the expression patterns of these genes in different species can be clustered into four categories.
conclusionsThe study describes a global characterization of DNA methylation-related genes in the plant kingdom. The similarities and differences in origin time, gene structure and phylogenetic relationship of these genes lead us to understand the evolutionary conservation and dynamics of DNA methylation in plants.
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