Evidence map›Paper›PMID 31299413›Full record

ArticleLeukemia research2019

Interleukin-8 blockade prevents activated endothelial cell mediated proliferation and chemoresistance of acute myeloid leukemia.

Vindhya Vijay, Regan Miller, Gau Shoua Vue, Mida Bahareh Pezeshkian, Michael Maywood, Allison M Ast, Leylah M Drusbosky, Yuri Pompeu, Alan D Salgado, Samuel D Lipten and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Leukemia research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 44 citations in OpenAlex.

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  3. Frontiers in oncology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Vindhya VijayDivision of Hematology and Oncology, Department of Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.
Regan MillerDepartment of Biological Sciences, Oakland University, Rochester, MI, USA.
Gau Shoua VueDepartment of Biological Sciences, Oakland University, Rochester, MI, USA.
Mida Bahareh PezeshkianDepartment of Biological Sciences, Oakland University, Rochester, MI, USA.
Michael MaywoodDepartment of Biological Sciences, Oakland University, Rochester, MI, USA.
Allison M AstDivision of Hematology and Oncology, Department of Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.
Leylah M DrusboskyDivision of Hematology and Oncology, Department of Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.
Yuri PompeuDepartment of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.
Alan D SalgadoDivision of Hematology and Oncology, Department of Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.
Samuel D LiptenDivision of Hematology and Oncology, Department of Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.
Timothy GeddesDepartment of Radiation Oncology, William Beaumont Health System, Royal Oak, MI, USA.
Ann Marie BlencDepartment of Hematopathology, William Beaumont Health System, Royal Oak, MI, USA.
Yubin GeDepartment of Oncology, Wayne State University School of Medicine, Detroit, MI, USA; Molecular Therapeutics Program and Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA.
David A OstrovDepartment of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.
Christopher R CogleDivision of Hematology and Oncology, Department of Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.
Gerard J MadlambayanDepartment of Biological Sciences, Oakland University, Rochester, MI, USA. Electronic address: madlamba@oakland.edu.
University of Florida · USOakland University · USBeaumont Health · USWayne State University · US

Funding

Endothelial Cell Activation Regulates AML Growth and RelapseR15CA182889 · NCI · OAKLAND UNIVERSITY · PI MADLAMBAYAN, GERARD JAMES · 2014 to 2014
$430k
NCI NIH HHS R15 CA182889
6 · The paper itself

Abstract

One of the greatest challenges in treating acute myeloid leukemia (AML) is chemotherapy refractory disease. Previously, we demonstrated a novel mechanism whereby AML-induced endothelial cell (EC) activation leads to subsequent leukemia cell adherence, quiescence and chemoresistance, identifying activated ECs as potential mediators of relapse. We now show mechanistically that EC activation induces the secretion of interleukin-8 (IL-8) leading to significant expansion of non-adherent AML cells and resistance to cytarabine (Ara-C). Through crystallography and computational modeling, we identified a pocket within IL-8 responsible for receptor binding, screened for small molecules that fit within this pocket, and blocked IL-8 induced proliferation and chemo-protection of AML cells with a hit compound. Results from this study show a new therapeutic strategy for targeting the sanctuary of an activated leukemia microenvironment.

Indexed as

Drug Resistance, NeoplasmAntineoplastic AgentsBiomarkersCell Line, TumorCell ProliferationCell SurvivalCytarabineEndothelial CellsHumansInterleukin-8Leukemia, Myeloid, AcuteModels, MolecularStructure-Activity RelationshipAntineoplastic AgentsBiomarkersCytarabineInterleukin-8Acute myeloid leukemiaChemoresistanceEndothelial cellInterleukin-8MicroenvironmentVascular niche

Identifiers

PMID31299413
PMCPMC6857733
OpenAlexW2955097599

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.