ArticleJournal of affective disorders2019
Association between epigenetic age acceleration and depressive symptoms in a prospective cohort study of urban-dwelling adults.
Article in Journal of affective disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Monocyte epigenetic age acceleration is linked to non-somatic depressive symptoms in women with and without HIV.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Epigenetic aging markers in the association between frailty and mortality among U.S. adults.BMC medicine · 2026Article
- Psychological distress in older adults: associations with epigenetic markers of ageing, inflammation, and depression, and joint effects on mortality.Brain, behavior, & immunity - health · 2025Article
- Work-related stress and burnout: Is epigenetic aging the missing link?Clinical epigenetics · 2025Article
- Telomere Length, Epigenetic Age Acceleration, and Mortality Risk in US Adult Populations: An Additive Bayesian Network Analysis.Aging cell · 2025Article
- Adolescent empathy and epigenetic aging in adulthood: Substance use as a mediator.Developmental psychology · 2025Article
- No association of posttraumatic stress disorder with epigenetic aging in women at mid-life: A longitudinal cohort study.Brain, behavior, and immunity · 2025Article
- Article
- Are depressive symptoms associated with biological aging in a cross-sectional analysis of adults over age 50 in the United States.Psychology and aging · 2024Article
- Longitudinal association of homocysteine with depressive and anxiety symptoms among urban adults: healthy aging in neighborhoods of diversity across the life span study.Translational psychiatry · 2024Article
- Article
- Poor sleep quality, dementia status and their association with all-cause mortality among older US adults.Aging · 2024Article
- The Impact of Childhood Mental Health and Substance Use on Methylation Aging Into Adulthood.Journal of the American Academy of Child and Adolescent Psychiatry · 2024Article
- The embodiment of parental death in early life through accelerated epigenetic aging: Implications for understanding how parental death before 18 shapes age-related health risk among older adults.SSM - population health · 2024Article
- Article
- Associations of depression and anxiety symptoms in childhood and adolescence with epigenetic aging.Journal of affective disorders · 2024Article
- Association of Neighborhood Deprivation and Depressive Symptoms With Epigenetic Age Acceleration: Evidence From the Canadian Longitudinal Study on Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Associations of stress and stress-related psychiatric disorders with GrimAge acceleration: review and suggestions for future work.Translational psychiatry · 2023Review
- Stressful life events and accelerated biological aging over time in youths.Psychoneuroendocrinology · 2023Article
- Genome-Environment Interactions and Psychiatric Disorders.Biomedicines · 2023Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectiveThis study tests associations of DNA methylation-based (DNAm) measures of epigenetic age acceleration (EAA) with cross-sectional and longitudinal depressive symptoms in an urban sample of middle-aged adults.
methodsWhite and African-American adult participants in the Healthy Aging in Neighborhoods of Diversity across the Life Span study for whom DNA samples were analyzed (baseline age: 30-65 years) we included. We estimated three DNAm based EAA measures: (1) universal epigenetic age acceleration (AgeAccel); (2) intrinsic epigenetic age acceleration (IEAA); and (3) extrinsic epigenetic age acceleration (EEAA). Depressive symptoms were assessed using the 20-item Center for Epidemiological Studies-Depression scale total and sub-domain scores at baseline (2004-2009) and follow-up visits (2009-2013). Linear mixed-effects regression models were conducted, adjusting potentially confounding covariates, selection bias and multiple testing (N = 329 participants, ∼52% men, k = 1.9 observations/participant, mean follow-up time∼4.7 years).
resultsNone of the epigenetic age acceleration measures were associated with total depressive symptom scores at baseline or over time. IEAA - a measure of cellular epigenetic age acceleration irrespective of white blood cell composition - was cross-sectionally associated with decrement in "positive affect" in the total population (γ LIMITATIONS: Limitations included small sample size, weak-moderate effects and measurement error.
conclusionsIEAA and AgeAccel, two measures of EAA using Horvath algorithm, were linked to a reduced "positive affect", overall and among Whites. Future studies are needed to replicate our findings and test bi-directional relationships.
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