Evidence map›Paper›PMID 31299383›Full record

ArticleBone2019

Cbl-PI3K interaction regulates Cathepsin K secretion in osteoclasts.

Jungeun Yu, Naga Suresh Adapala, Laura Doherty, Archana Sanjay

Open access · greenAbstract read
In one paragraph

Article in Bone, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Parental Origin ofJBMR plus · 2022
    Article
  5. Article
  6. The crosstalk between MYC and mTORC1 during osteoclastogenesis.Frontiers in cell and developmental biology · 2022
    Article
  7. Article
  8. Article
  9. Cathepsin K: The Action in and Beyond Bone.Frontiers in cell and developmental biology · 2020
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jungeun YuDepartment of Orthopaedic Surgery, UConn Health, Farmington, CT 06030, United States of America.
Naga Suresh AdapalaDepartment of Orthopaedic Surgery, UConn Health, Farmington, CT 06030, United States of America.
Laura DohertyDepartment of Orthopaedic Surgery, UConn Health, Farmington, CT 06030, United States of America.
Archana SanjayDepartment of Orthopaedic Surgery, UConn Health, Farmington, CT 06030, United States of America. Electronic address: asanjay@uchc.edu.
UConn Health · US

Funding

Regulation of Osteoclast Function : Role of the Cbl-PI3K ComplexR01AR055601 · NIAMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI SANJAY, ARCHANA · 2008 to 2012
$1.6M
NIAMS NIH HHS R01 AR055601
6 · The paper itself

Abstract

Effective bone resorption by osteoclasts is critical for balanced bone remodeling. We have previously reported that mice harboring a substitution mutation of tyrosine 737 to phenylalanine in the adapter protein Cbl (Cbl

Indexed as

ActinsAnimalsBone ResorptionCathepsin KCulture Media, ConditionedCytoplasmic VesiclesHyaluronic AcidLysosomal-Associated Membrane Protein 2Mice, Inbred C57BLMutationOsteoclastsOsteogenesisPhosphatidylinositol 3-KinasesProtein BindingProto-Oncogene Proteins c-cblActinsCathepsin KCulture Media, ConditionedHyaluronic AcidLysosomal-Associated Membrane Protein 2Phosphatidylinositol 3-KinasesProto-Oncogene Proteins c-cblCathepsin KLAMP2OsteoclastPI3K and CblVesicular trafficking

Identifiers

PMID31299383
PMCPMC6708784
OpenAlexW2959825828

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.