Evidence map›Paper›PMID 31299340›Full record

ArticleNitric oxide : biology and chemistry2019

Inhaled nebulized nitrite and nitrate therapy in a canine model of hypoxia-induced pulmonary hypertension.

Irene Cortés-Puch, Junfeng Sun, Alan N Schechter, Steven B Solomon, Ji Won Park, Jing Feng, Cameron Gilliard, Charles Natanson, Barbora Piknova

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nitric oxide : biology and chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Nitric Oxide and Endothelial Dysfunction.Critical care clinics · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Irene Cortés-PuchNational Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, MD, USA; Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA; Division of Pulmonary, Critical Care and Sleep Medicine, University of California Davis, Sacramento, CA, USA.
Junfeng SunCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Alan N SchechterNational Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, MD, USA.
Steven B SolomonCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Ji Won ParkNational Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, MD, USA.
Jing FengCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Cameron GilliardNational Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, MD, USA; Penn State Health Milton S. Hershey Medical Center, Department of Anesthesia and Perioperative Medicine, Hershey, PA, USA.
Charles NatansonCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Barbora PiknovaNational Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, MD, USA. Electronic address: barbora.piknova@nih.gov.
National Institutes of Health Clinical Center · USNational Institutes of Health · USNational Institute of Diabetes and Digestive and Kidney Diseases · US

Funding

Clinical Applications of Nitrite and NitrateZIADK025104 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI SCHECHTER, ALAN · 2009 to 2025
$10.4M
Clinical Applications of NitriteZ01DK025104 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI SCHECHTER, ALAN · 2007 to 2008
$738k
Intramural NIH HHS Z01 DK025104
6 · The paper itself

Abstract

Dysfunction in the nitric oxide (NO) signaling pathway can lead to the development of pulmonary hypertension (PH) in mammals. Discovery of an alternative pathway to NO generation involving reduction from nitrate to nitrite and to NO has motivated the evaluation of nitrite as an alternative to inhaled NO for PH. In contrast, inhaled nitrate has not been evaluated to date, and potential benefits include a prolonged half-life and decreased risk of methemoglobinemia. In a canine model of acute hypoxia-induced PH we evaluated the effects of inhaled nitrate to reduce pulmonary arterial pressure (PAP). In a randomized controlled trial, inhaled nitrate was compared to inhaled nitrite and inhaled saline. Exhaled NO, PAP and systemic blood pressures were continuously monitored. Inhaled nitrite significantly decreased PAP and increased exhaled NO. In contrast, inhaled nitrate and inhaled saline did not decrease PAP or increase exhaled NO. Unexpectedly, we found that inhaled nitrite resulted in prolonged (>5 h) exhaled NO release, increase in nitrate venous/arterial levels and a late surge in venous nitrite levels. These findings do not support a therapeutic role for inhaled nitrate in PH but may have therapeutic implications for inhaled nitrite in various disease states.

Indexed as

Administration, InhalationAnimalsDogsHypertension, PulmonaryHypoxiaNitratesNitric OxideRatsSodium NitriteNitratesNitric Oxidesodium nitrateSodium Nitrite

Identifiers

PMID31299340
PMCPMC7341979
OpenAlexW2961322121

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.