Evidence map›Paper›PMID 31298844›Full record

ArticleBiochemistry2019

An Isoform-Selective PTP1B Inhibitor Derived from Nitrogen-Atom Augmentation of Radicicol.

Taoda Shi, E M Kithsiri Wijeratne, Cristian Solano, Andrew J Ambrose, Alison B Ross, Charles Norwood, Charles K Orido, Tigran Grigoryan, Joseph Tillotson, Minjin Kang and 7 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 2 countries.

Taoda ShiDepartment of Pharmacology and Toxicology, College of Pharmacy , University of Arizona , 1703 East Mabel Street , P.O. Box 210207, Tucson , Arizona 85721 , United States.
E M Kithsiri WijeratneNatural Products Center, School of Natural Resources and the Environment, College of Agriculture and Life Sciences , University of Arizona , 250 East Valencia Road , Tucson , Arizona 85706 , United States.
Cristian SolanoDepartment of Pharmacology and Toxicology, College of Pharmacy , University of Arizona , 1703 East Mabel Street , P.O. Box 210207, Tucson , Arizona 85721 , United States.
Andrew J AmbroseDepartment of Pharmacology and Toxicology, College of Pharmacy , University of Arizona , 1703 East Mabel Street , P.O. Box 210207, Tucson , Arizona 85721 , United States.ORCID 0000-0002-2932-4514
Alison B RossDepartment of Pharmacology and Toxicology, College of Pharmacy , University of Arizona , 1703 East Mabel Street , P.O. Box 210207, Tucson , Arizona 85721 , United States.
Charles NorwoodDepartment of Pharmacology and Toxicology, College of Pharmacy , University of Arizona , 1703 East Mabel Street , P.O. Box 210207, Tucson , Arizona 85721 , United States.
Charles K OridoDepartment of Pharmacology and Toxicology, College of Pharmacy , University of Arizona , 1703 East Mabel Street , P.O. Box 210207, Tucson , Arizona 85721 , United States.
Tigran GrigoryanDepartment of Pharmacology and Toxicology, College of Pharmacy , University of Arizona , 1703 East Mabel Street , P.O. Box 210207, Tucson , Arizona 85721 , United States.
Joseph TillotsonDepartment of Pharmacology and Toxicology, College of Pharmacy , University of Arizona , 1703 East Mabel Street , P.O. Box 210207, Tucson , Arizona 85721 , United States.
Minjin KangDepartment of Pharmacology and Toxicology, College of Pharmacy , University of Arizona , 1703 East Mabel Street , P.O. Box 210207, Tucson , Arizona 85721 , United States.
Gang LuoDepartment of Pharmacology and Toxicology, College of Pharmacy , University of Arizona , 1703 East Mabel Street , P.O. Box 210207, Tucson , Arizona 85721 , United States.
Bradley M KeeganDepartment of Chemistry and Biochemistry , The University of Notre Dame , 251 Nieuwland Science Hall , Notre Dame , Indiana 46556 , United States.
Wenhao HuSchool of Pharmaceutical Sciences , Sun Yat-sen University , Guangzhou , China , 510006.ORCID 0000-0002-1461-3671
Brian S J BlaggDepartment of Chemistry and Biochemistry , The University of Notre Dame , 251 Nieuwland Science Hall , Notre Dame , Indiana 46556 , United States.ORCID 0000-0002-6200-3480
Donna D ZhangDepartment of Pharmacology and Toxicology, College of Pharmacy , University of Arizona , 1703 East Mabel Street , P.O. Box 210207, Tucson , Arizona 85721 , United States.
A A Leslie GunatilakaNatural Products Center, School of Natural Resources and the Environment, College of Agriculture and Life Sciences , University of Arizona , 250 East Valencia Road , Tucson , Arizona 85706 , United States.
Eli ChapmanDepartment of Pharmacology and Toxicology, College of Pharmacy , University of Arizona , 1703 East Mabel Street , P.O. Box 210207, Tucson , Arizona 85721 , United States.ORCID 0000-0002-6310-1664
University of Arizona · USUniversity of Notre Dame · USSun Yat-sen University · CN

Funding

Training in Environmental Toxicology of Human DiseaseT32ES007091 · NIEHS · UNIVERSITY OF ARIZONA · PI Nathan J Cherrington · 1985 to 2026
$10.7M
CHEMISTRY-BIOLOGY INTERFACE TRAINING PROGRAMT32GM008804 · NIGMS · UNIVERSITY OF ARIZONA · PI MONTFORT, WILLIAM R. · 2003 to 2023
$3.9M
Anticancer Agents from Plant- and Lichen-Associated Fungi of the Sonoran DesertR01CA090265 · NCI · UNIVERSITY OF ARIZONA · PI GUNATILAKA, LESLIE · 2002 to 2013
$2.2M
Diverse Molecular Libraries from Unique Endosymbiotic FungiP41GM094060 · NIGMS · UNIVERSITY OF ARIZONA · PI GUNATILAKA, LESLIE · 2010 to 2012
$867k
NCI NIH HHS R01 CA090265NIEHS NIH HHS T32 ES007091NIGMS NIH HHS P41 GM094060NIGMS NIH HHS T32 GM008804
6 · The paper itself

Abstract

A library of natural products and their derivatives was screened for inhibition of protein tyrosine phosphatase (PTP) 1B, which is a validated drug target for the treatment of obesity and type II diabetes. Of those active in the preliminary assay, the most promising was compound

Indexed as

AnimalsEnzyme InhibitorsMacrolidesMiceNitrogenProtein BindingProtein IsoformsProtein Structure, TertiaryProtein Tyrosine Phosphatase, Non-Receptor Type 1Enzyme InhibitorsMacrolidesmonordenNitrogenProtein IsoformsProtein Tyrosine Phosphatase, Non-Receptor Type 1PTPN1 protein, human

Identifiers

PMID31298844
PMCPMC8610018
OpenAlexW2958552573

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.