ArticleJournal of the National Cancer Institute2020
Mammographic Density Change and Risk of Breast Cancer.
Article in Journal of the National Cancer Institute, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Repeated measures of mammographic density and texture to evaluate prediction and risk of breast cancer: a systematic review of the methods used in the literature.Cancer causes & control : CCC · 2023Pooled it
- A Randomized Controlled Trial of Soy Isoflavone Intake on Mammographic Density among Malaysian Women.Nutrients · 2023Trial
- Improving preventive screening efficiency: A population-based model of age-specific mammographic density for breast Cancer detection in Saudi Arabia.Preventive medicine reports · 2025Article
- Assessing mammographic density change within individuals across screening rounds using deep learning-based software.Journal of medical imaging (Bellingham, Wash.) · 2025Article
- Breast Density Changes after Risk-Reducing Salpingo-oophorectomy in Women with a Pathogenic Germline Variant in BRCA1 or BRCA2.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
- The impact of changes in breast density over time on breast cancer risk.Scientific reports · 2025Article
- Mammographic density by time and breast: a retrospective cohort study from BreastScreen Norway.Breast cancer research : BCR · 2025Article
- Incidence and Risk Factors of Interval and Screen-Detected Breast Cancer.JAMA oncology · 2025Article
- Artificial intelligence and consistency in patient care: a large-scale longitudinal study of mammographic density assessment.BJR artificial intelligence · 2025Article
- Development and validation of the surmising model for volumetric breast density using X-ray exposure conditions in digital mammography.Medical & biological engineering & computing · 2025Article
- Hormone Signaling in Breast Development and Cancer.Advances in experimental medicine and biology · 2025Review
- Trajectories of breast density change over time and subsequent breast cancer risk: longitudinal study.BMJ (Clinical research ed.) · 2024Article
- Longitudinal history of mammographic breast density and breast cancer risk by familial risk, menopausal status, and initial mammographic density level in a high risk cohort: a nested case-control study.Breast cancer research : BCR · 2024Article
- Mammographic density in relationships with relevant contributing factors: a multicentric study from Riyadh, Saudi Arabia.Gland surgery · 2024Article
- Temporal changes in mammographic breast density and breast cancer risk among women with benign breast disease.Breast cancer research : BCR · 2024Article
- Practical Challenges of DBT-Guided VABB: Harms and Benefits, from Literature to Clinical Experience.Cancers · 2023Article
- Development and evaluation of a method to assess breast cancer risk using a longitudinal history of mammographic density: a cohort study.Breast cancer research : BCR · 2023Article
- Studying the association between longitudinal mammographic density measurements and breast cancer risk: a joint modelling approach.Breast cancer research : BCR · 2023Article
- Changes in mammographic density and risk of breast cancer among a diverse cohort of women undergoing mammography screening.Breast cancer research and treatment · 2023Article
- The FEDRA Longitudinal Study: Repeated Volumetric Breast Density Measures and Breast Cancer Risk.Cancers · 2023Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe examined the association between annual mammographic density change (MDC) and breast cancer (BC) risk, and how annual MDC influences the association between baseline mammographic density (MD) and BC risk.
methodsWe used the Karolinska Mammography Project for Risk Prediction of Breast Cancer cohort of Swedish women (N = 43 810) aged 30-79 years with full access to BC risk factors and mammograms. MD was measured as dense area (cm2) and percent MD using the STRATUS method. We used the contralateral mammogram for women with BC and randomly selected a mammogram from either left or right breast for healthy women. We calculated relative area MDC between repeated examinations. Relative area MDC was categorized as decreased (>10% decrease per year), stable (no change), or increased (>10% increase per year). We used Cox proportional hazards regression to estimate the association of BC with MDC and interaction analysis to investigate how MDC modified the association between baseline MD and BC risk. All tests of statistical significance were two-sided.
resultsIn all, 563 women were diagnosed with BC. Compared with women with a decreased MD over time, no statistically significant difference in BC risk was seen for women with either stable MD or increasing MD (hazard ratio = 1.01, 95% confidence interval = 0.82 to 1.23, P = .90; and hazard ratio = 0.98, 95% confidence interval = 0.80 to 1.22, P = .90, respectively). Categorizing baseline MD and subsequently adding MDC did not seem to influence the association between baseline MD and BC risk.
conclusionsOur results suggest that annual MDC does not influence BC risk. Furthermore, MDC does not seem to influence the association between baseline MD and BC risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.