ArticleJournal of cognitive neuroscience2019
The Functional Roles of the Amygdala and Prefrontal Cortex in Processing Uncertainty.
Article in Journal of cognitive neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed.
- Differences in other-directed emotion regulation tracks connectivity between amygdala and prefrontal regions during fairness decisions.bioRxiv : the preprint server for biology · 2026Article
- Modeling value integration during decision making under uncertainty with the Florida and Georgia gambling task.Scientific reports · 2025Article
- Developmental differences in social information use under uncertainty: A neurocomputational approach.Developmental cognitive neuroscience · 2025Article
- Neural correlates of Bayesian social belief updating in the medial prefrontal cortex.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Active information sampling in health and disease.Neuroscience and biobehavioral reviews · 2025Review
- Social Risk Coding by Amygdala Activity and Connectivity with the Dorsal Anterior Cingulate Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Uncertainty deconstructed: conceptual analysis and state-of-the-art review of the ERP correlates of risk and ambiguity in decision-making.Cognitive, affective & behavioral neuroscience · 2023Review
- A Fluid Self-Concept: How the Brain Maintains Coherence and Positivity across an Interconnected Self-Concept While Incorporating Social Feedback.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Early caregiving adversity differentially shapes behavioral sensitivity to reward and risk during decision-making.Journal of experimental psychology. General · 2022Article
- Representations and decodability of diverse cognitive functions are preserved across the human cortex, cerebellum, and subcortex.Communications biology · 2022Article
- Putting the "mental" back in "mental disorders": a perspective from research on fear and anxiety.Molecular psychiatry · 2022Review
- Developmental Dyslexia: Environment Matters.Brain sciences · 2021Article
- An ALE Meta-Analysis on Investment Decision-Making.Brain sciences · 2021Review
- Neural Computations of Threat.Trends in cognitive sciences · 2021Review
- Dyslexia as an adaptation to cortico-limbic stress system reactivity.Neurobiology of stress · 2020Review
- An Evolutionary Perspective of Dyslexia, Stress, and Brain Network Homeostasis.Frontiers in human neuroscience · 2020Review
- Thinking fast or slow? Functional magnetic resonance imaging reveals stronger connectivity when experienced neurologists diagnose ambiguous cases.Brain communications · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Decisions under uncertainty distinguish between those made under risk (known probabilities) and those made under ambiguity (unknown probabilities). Despite widespread interest in decisions under uncertainty and the successful documentation that these distinct psychological constructs profoundly-and differentially-impact behavior, research has not been able to systematically converge on which brain regions are functionally involved in processing risk and ambiguity. We merge a lesion approach with computational modeling and simultaneous measurement of the arousal response to investigate the impact the medial prefrontal cortex (mPFC), lateral prefrontal cortex (lPFC), and amygdala have on decisions under uncertainty. Results reveal that the lPFC acts as a unitary system for processing uncertainty: Lesions to this region disrupted the relationship between arousal and choice, broadly increasing both risk and ambiguity seeking. In contrast, the mPFC and amygdala appeared to play no role in processing risk, and the mPFC only had a tenuous relationship with ambiguous uncertainty. Together, these findings reveal that only the lPFC plays a global role in processing the highly aversive nature of uncertainty.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.