Evidence map›Paper›PMID 31298609›Full record

ArticleJournal of neurotrauma2020

Dextran 500 Improves Recovery of Inflammatory Markers: An

Susan Giorgi-Coll, Eric Peter Thelin, Caroline Lindblad, Tamara Tajsic, Keri L H Carpenter, Peter J A Hutchinson, Adel Helmy

Open access · hybridAbstract read
In one paragraph

Article in Journal of neurotrauma, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Susan Giorgi-CollDivision of Neurosurgery, Department of Clinical Neurosciences, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.
Eric Peter ThelinDivision of Neurosurgery, Department of Clinical Neurosciences, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.
Caroline LindbladDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Tamara TajsicDivision of Neurosurgery, Department of Clinical Neurosciences, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.
Keri L H CarpenterDivision of Neurosurgery, Department of Clinical Neurosciences, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.
Peter J A HutchinsonDivision of Neurosurgery, Department of Clinical Neurosciences, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.
Adel HelmyDivision of Neurosurgery, Department of Clinical Neurosciences, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.
University of Cambridge · GBKarolinska Institutet · SEKarolinska University Hospital · SE

Funding

Medical Research Council G0600986Medical Research Council G0802251
6 · The paper itself

Abstract

Cerebral microdialysis (CMD) is used in severe traumatic brain injury (TBI) in order to recover metabolites in brain extracellular fluid (ECF). To recover larger proteins and avoid fluid loss, albumin supplemented perfusion fluid (PF) has been utilized, but because of regulatory changes in the European Union, this is no longer practicable. The aim with this study was to see whether fluid, absolute (AR), and relative (RR) recovery for the novel carrier, Dextran 500, was better than conventional PF for a range of cytokines and chemokines. An

Indexed as

DextransBiomarkersBrain Injuries, TraumaticCytokinesExtracellular FluidHumansInflammationIn Vitro TechniquesMicrodialysisBiomarkersCytokinesDextranschemokinescytokinesDextran 500in vitromicrodialysisrecovery

Identifiers

PMID31298609
PMCPMC6921287
OpenAlexW2956203766

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.