ArticleNeurosurgery2019
The Safety and Efficacy of Continuous Tirofiban as a Monoantiplatelet Therapy in the Management of Ruptured Aneurysms Treated Using Stent-Assisted Coiling or Flow Diversion and Requiring Ventricular Drainage.
Article in Neurosurgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04219774 (Neurocognitive Impairment Assessment in Symptomatic Carotid Occlusion Recanalized Endovascularly), which is not on this map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neurocognitive Impairment Assessment in Symptomatic Carotid Occlusion Recanalized Endovascularly
Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Intravenous Tirofiban for Preventing Acute In-Stent Thrombosis in Emergent Carotid Artery Stenting: a Systematic Review and Meta-Analysis.Clinical neuroradiology · 2025Pooled it
- Safety and efficacy of tirofiban in the endovascular treatment of intracranial aneurysms: a systematic evaluation and meta-analysis.Neurosurgical review · 2025Pooled it
- Effect of antiplatelet treatment on aneurysmal subarachnoid hemorrhage patients after endovascular treatment: a systematic review with meta-analysis.Neurosurgical review · 2022Pooled it
- Trial
- Woven EndoBridge versus stent-assisted coil embolization for the treatment of ruptured wide-necked aneurysms: A multicentric experience.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026Article
- Secondary risks of bleeding and associated outcome after tirofiban application during interventional treatment of intracranial aneurysms.Brain & spine · 2026Article
- Multicenter comparison of antiplatelet treatment strategies for urgent/emergent neuroendovascular stenting.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Review
- Intravenous tenecteplase thrombolysis and endovascular bridging intra-arterial tirofiban injection therapy in a pediatric case of acute ischemic stroke.BMC neurology · 2025Article
- Role and Safety of Tirofiban in Peri-Interventional Antiplatelet Management for Aneurysm Treatment.Clinical neuroradiology · 2025Article
- Safety and effectiveness of Neuroform Atlas stent-assisted coil embolization for ruptured intracranial aneurysms.Journal of cerebrovascular and endovascular neurosurgery · 2024Article
- Use of Tirofiban to Prevent Ischemic Events in Patients with CYP2C19 Loss-of-Function Alleles during Flow Diversion of Intracranial Aneurysm: A Multicenter Cohort Study.Translational stroke research · 2024Article
- Comparison of Angiographic Outcomes of Woven EndoBridge and Balloon-Assisted Coiling for the Treatment of Ruptured Wide-Necked Aneurysms: A Multicentric Study.Stroke (Hoboken, N.J.) · 2024Article
- Safety and efficacy of endovascular treatment for tiny ruptured intracranial aneurysms with low-profile visualized intraluminal support stents.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2023Article
- Stent-Assisted Coiling Versus Balloon-Assisted Coiling for the Treatment of Ruptured Wide-Necked Aneurysms: A 2-Center Experience.Stroke (Hoboken, N.J.) · 2023Article
- Pathophysiology of Delayed Cerebral Ischemia After Subarachnoid Hemorrhage: A Review.Journal of the American Heart Association · 2021Review
- In Reply: Tirofiban Protocol Protects Against Delayed Cerebral Ischemia: A Case-Series Study.Neurosurgery · 2021Article
- Safety and efficacy of stent-assisted coiling for acutely ruptured wide-necked intracranial aneurysms: comparison of LVIS stents with laser-cut stents.Chinese neurosurgical journal · 2021Article
- Treatment of the acute thromboembolic event during endovascular embolization of intracranial aneurysm.Journal of interventional medicine · 2020Article
- Commentary to: Ticagrelor Use in Indian Patients Undergoing Neuroendovascular Procedures: A Single-Center Experience.Neurointervention · 2020Article
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundHemorrhagic complications are a major concern for aneurysmal subarachnoid hemorrhage patients treated with stenting or stent-assisted coiling and undergoing additional procedures such as shunting, ventriculostomy placement, and craniotomies/craniectomies.
objectiveTo assess the safety and efficacy of using a continuous infusion of tirofiban as a monoantiplatelet therapy in the management of ruptured aneurysms in the setting of either stent-assisted coiling (SAC) or flow diversion devices (FDD) in patients requiring either an external ventricular drain (EVD) or ventriculoperitoneal shunt (VPS).
methodsAneurysmal subarachnoid hemorrhage (aSAH) patients between July 2017 and September 2018 who were treated with SAC or FDD were started on a continuous tirofiban infusion protocol (0.10 μg/kg/min) with no preceding loading dose as a monoantiplatelet therapy. Safety analysis was performed retrospectively to assess the complication rate, hemorrhagic rate, and rate of ischemic events. There were no hemorrhages related to the VPS surgery.
resultsNineteen subjects were included in the series. The patients received a total of 25 procedures that included 19 EVDs and 6 VPSs. Two patients (8.3%) developed small asymptomatic track hemorrhages after EVD placement. One patient developed a large retroperitoneal hemorrhage due to renal artery branch injury during procedure, and another patient developed an idiosyncratic transient thrombocytopenia which resolved after stopping the medication. One patient (4%) developed a transient ischemic attack, which resolved after a bolus of tirofiban.
conclusionOur study suggests that long-term use of intravenous tirofiban monotherapy in aSAH subjects for endovascular SAC or FDD is safe in the perioperative setting.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.