Evidence map›Paper›PMID 31298287›Full record

ArticleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2020

Association between dietary zinc intake and abdominal aortic calcification in US adults.

Wei Chen, Ruth Eisenberg, Wenzhu B Mowrey, Judith Wylie-Rosett, Matthew K Abramowitz, David A Bushinsky, Michal L Melamed

Open access · greenAbstract read
In one paragraph

Article in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 118 citations in OpenAlex.

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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Wei ChenDepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
Ruth EisenbergDepartment of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
Wenzhu B MowreyDepartment of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
Judith Wylie-RosettDepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
Matthew K AbramowitzDepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
David A BushinskyDepartment of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
Michal L MelamedDepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
Albert Einstein College of Medicine · USUniversity of Rochester · US

Funding

New York Regional Center for Diabetes Translation Research - Translational Intervention Methodology CoreP30DK111022 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI JEFFREY GONZALEZ · 2016 to 2026
$7.8M
Hypercalciuria and Bone Quality in the Genetic Hypercalciuric Stone-Forming RatsR01DK075462 · NIDDK · UNIVERSITY OF ROCHESTER · PI BUSHINSKY, DAVID A · 2008 to 2019
$3.8M
Calcification Propensity, using Dynamic Light Scattering, to Study Vascular Calcification in Patients with Advanced Chronic Kidney DiseaseK23DK114476 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI CHEN, WEI · 2018 to 2021
$953k
Inflammation, muscle wasting, and physical function in chronic kidney diseaseK23DK099438 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI ABRAMOWITZ, MATTHEW K · 2014 to 2018
$946k
Characterization and novel imaging of skeletal muscle fibrosis in patients with chronic kidney diseaseR03DK116023 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI ABRAMOWITZ, MATTHEW K · 2018 to 2019
$182k
NIDDK NIH HHS K23 DK099438NIDDK NIH HHS K23 DK114476NIDDK NIH HHS P30 DK111022NIDDK NIH HHS R01 DK075462NIDDK NIH HHS R03 DK116023
6 · The paper itself

Abstract

backgroundIn animal studies, zinc supplementation inhibited phosphate-induced arterial calcification. We tested the hypothesis that higher intake of dietary zinc was associated with lower abdominal aortic calcification (AAC) among adults in the USA. We also explored the associations of AAC with supplemental zinc intake, total zinc intake and serum zinc level.

methodsWe performed cross-sectional analyses of 2535 participants from the National Health and Nutrition Examination Survey 2013-14. Dietary and supplemental zinc intakes were obtained from two 24-h dietary recall interviews. Total zinc intake was the sum of dietary and supplemental zinc. AAC was measured using dual-energy X-ray absorptiometry in adults ≥40 years of age and quantified using the Kauppila score system. AAC scores were categorized into three groups: no AAC (AAC = 0, reference group), mild-moderate (AAC >0-≤6) and severe AAC (AAC >6).

resultsDietary zinc intake (mean ± SE) was 10.5 ± 0.1 mg/day; 28% had AAC (20% mild-moderate and 8% severe), 17% had diabetes mellitus and 51% had hypertension. Higher intake of dietary zinc was associated with lower odds of having severe AAC. Per 1 mg/day higher intake of dietary zinc, the odds of having severe AAC were 8% lower [adjusted odds ratio 0.92 (95% confidence interval 0.86-0.98), P = 0.01] compared with those without AAC, after adjusting for demographics, comorbidities and laboratory measurements. Supplemental zinc intake, total zinc intake and serum zinc level were not associated with AAC.

conclusionsHigher intake of dietary zinc was independently associated with lower odds of having severe AAC among noninstitutionalized US adults.

Indexed as

DietAdultAgedAorta, AbdominalAortic DiseasesCross-Sectional StudiesFemaleHumansMaleMiddle AgedNutritional StatusNutrition SurveysPrognosisUnited StatesVascular CalcificationZincZinccardiovascular diseasemineral metabolismnutritionvascular calcificationzinc

Identifiers

PMID31298287
PMCPMC7417001
OpenAlexW2961291461

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.