Evidence map›Paper›PMID 31298273›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2020

Eight-day Inpatient Directly Observed Therapy for Antiretroviral Therapy (ART) Failure: A Tool For Preventing Unnecessary ART Changes and Optimizing Adherence Support.

Nicole E Winchester, Frank Maldarelli, Yolanda Mejia, Nicola Dee, Robin Dewar, Elizabeth Laidlaw, Safia S Kuriakose, Pamela Stoll, Michael Proschan, H Clifford Lane and 1 more

Abstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nicole E WinchesterNational Institute of Allergy and Infectious Diseases, Bethesda.
Frank MaldarelliNational Cancer Institute, Frederick.
Yolanda MejiaClinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, National Cancer Institute, Bethesda, Maryland.
Nicola DeeClinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, National Cancer Institute, Bethesda, Maryland.
Robin DewarClinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, National Cancer Institute, Bethesda, Maryland.
Elizabeth LaidlawNational Institute of Allergy and Infectious Diseases, Bethesda.
Safia S KuriakoseClinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, National Cancer Institute, Bethesda, Maryland.
Pamela StollClinical Center, National Institutes of Health, Bethesda, Maryland.
Michael ProschanNational Institute of Allergy and Infectious Diseases, Bethesda.
H Clifford LaneNational Institute of Allergy and Infectious Diseases, Bethesda.
Alice K PauNational Institute of Allergy and Infectious Diseases, Bethesda.

Funding

Pathogenesis and Treatment of HIV InfectionZIAAI000585 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI LANE, CLIFFORD · 2009 to 2025
$26.8M
Clinical Interventional Studies of HIV ReservoirsZIABC011464 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI MALDARELLI, FRANK · 2012 to 2025
$13.2M
HIV-1 Genetic Variation in Infected IndividualsZIABC010819 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI MALDARELLI, FRANK · 2009 to 2025
$9.9M
CCR NIH HHS HHSN261200800001CNCI NIH HHS HHSN261200800001E
6 · The paper itself

Abstract

Eight-day inpatient directly observed therapy confirmed nonadherence as the major cause of virologic failure for 9 (45%) of 20 highly treatment-experienced persons with human immunodeficiency virus, extensive antiretroviral drug resistance, and high self-reported adherence rates, preventing unnecessary regimen changes.

Indexed as

Anti-HIV AgentsHIV-1HIV InfectionsAntiretroviral Therapy, Highly ActiveDirectly Observed TherapyDrug Resistance, ViralHumansInpatientsMedication AdherenceTreatment FailureViral LoadAnti-HIV Agentsadherenceantiretroviral therapydirectly observed therapydrug resistanceviral failure

Identifiers

PMID31298273
PMCPMC7319057

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.