ArticleCerebral cortex (New York, N.Y. : 1991)2020
Prefrontal Computation as Active Inference.
Article in Cerebral cortex (New York, N.Y. : 1991), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- The phantastic organ: predictive processing in the brain.Frontiers in psychology · 2026Review
- The myth of the Bayesian brain.European journal of applied physiology · 2025Review
- Developing algorithmic psychiatry via multi-level spanning computational models.Cell reports. Medicine · 2025Review
- Article
- RDoC Framework Through the Lens of Predictive Processing: Focusing on Cognitive Systems Domain.Computational psychiatry (Cambridge, Mass.) · 2024Review
- Cognitive effort and active inference.Neuropsychologia · 2023Article
- Flexible intentions: An Active Inference theory.Frontiers in computational neuroscience · 2023Article
- Geometry of neural computation unifies working memory and planning.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Integrated world modeling theory expanded: Implications for the future of consciousness.Frontiers in computational neuroscience · 2022Article
- An active inference model of conscious access: How cognitive action selection reconciles the results of report and no-report paradigms.Current research in neurobiology · 2022Article
- Evidence and implications of abnormal predictive coding in dementia.Brain : a journal of neurology · 2021Review
- Memory and Markov Blankets.Entropy (Basel, Switzerland) · 2021Article
- Simulating the computational mechanisms of cognitive and behavioral psychotherapeutic interventions: insights from active inference.Scientific reports · 2021Article
- Simulating lesion-dependent functional recovery mechanisms.Scientific reports · 2021Article
- Towards a computational phenomenology of mental action: modelling meta-awareness and attentional control with deep parametric active inference.Neuroscience of consciousness · 2021Article
- Active inference on discrete state-spaces: A synthesis.Journal of mathematical psychology · 2020Review
- Fast fronto-parietal cortical dynamics of conflict detection and context updating in a flanker task.Cognitive neurodynamics · 2020Article
- Prediction error signaling explains neuronal mismatch responses in the medial prefrontal cortex.PLoS biology · 2020Article
- Neuromodulatory Control and Language Recovery in Bilingual Aphasia: An Active Inference Approach.Behavioral sciences (Basel, Switzerland) · 2020Article
- Inferring What to Do (And What Not to).Entropy (Basel, Switzerland) · 2020Article
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4 authors.
Funding
Abstract
The prefrontal cortex is vital for a range of cognitive processes, including working memory, attention, and decision-making. Notably, its absence impairs the performance of tasks requiring the maintenance of information through a delay period. In this paper, we formulate a rodent task-which requires maintenance of delay-period activity-as a Markov decision process and treat optimal task performance as an (active) inference problem. We simulate the behavior of a Bayes optimal mouse presented with 1 of 2 cues that instructs the selection of concurrent visual and auditory targets on a trial-by-trial basis. Formulating inference as message passing, we reproduce features of neuronal coupling within and between prefrontal regions engaged by this task. We focus on the micro-circuitry that underwrites delay-period activity and relate it to functional specialization within the prefrontal cortex in primates. Finally, we simulate the electrophysiological correlates of inference and demonstrate the consequences of lesions to each part of our in silico prefrontal cortex. In brief, this formulation suggests that recurrent excitatory connections-which support persistent neuronal activity-encode beliefs about transition probabilities over time. We argue that attentional modulation can be understood as the contextualization of sensory input by these persistent beliefs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.