Evidence map›Paper›PMID 31298048›Full record

ArticleInternational journal of immunopathology and pharmacology

Effects of GIT-27NO, a NO-donating compound, on hepatic ischemia/reperfusion injury.

Katia Mangano, Raffaele Lanteri, Maria Sofia Basile, Noemi Bellavia, Rosalia Latino, Domenico Messina, Paolo Fagone, Giuseppe Colletti, Riccardo Nania, Rosario Caltabiano and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of immunopathology and pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Katia Mangano1 Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.
Raffaele Lanteri2 Department of General Surgery and Medical-Surgical Specialties, University of Catania, Catania, Italy.
Maria Sofia Basile1 Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.
Noemi Bellavia2 Department of General Surgery and Medical-Surgical Specialties, University of Catania, Catania, Italy.
Rosalia Latino2 Department of General Surgery and Medical-Surgical Specialties, University of Catania, Catania, Italy.
Domenico Messina1 Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.
Paolo Fagone1 Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.
Giuseppe Colletti1 Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.
Riccardo Nania1 Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.
Rosario Caltabiano3 Department of Surgical Sciences, Organ Transplantation and Advanced Technologies, G.F. Ingrassia, University of Catania, Catania, Italy.
Roberto Di Marco4 Department of Medicine and Health Sciences "Vincenzo Tiberio," University of Molise, Campobasso, Italy.ORCID https://orcid.org/0000-0001-5075-4597
Antonio Di Cataldo2 Department of General Surgery and Medical-Surgical Specialties, University of Catania, Catania, Italy.
University of Catania · ITUniversity of Molise · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatic ischemia/reperfusion injury (IRI) is a clinical condition that may lead to cellular injury and organ dysfunction that can be observed in different conditions, such as trauma, shock, liver resection, and transplantation. Moderate levels of nitric oxide (NO) produced by the endothelial isoform of the NO synthase protect against liver IRI. GIT-27NO is a NO-derivative of the toll-like receptor 4 antagonist VGX-1027 that has been shown to possess both antineoplastic and immunomodulatory properties in vitro and in vivo. In this study, we have investigated the effects of this compound in vitro, in a model of oxidative stress induced in HepG2 cells by hydrogen peroxide (H

Indexed as

AnimalsAntineoplastic AgentsAntioxidantsCell Line, TumorCell SurvivalDimethyl FumarateHepatocytesHep G2 CellsHumansHydrogen PeroxideLiverLiver DiseasesMaleNitric OxideOxadiazolesOxidative StressAntineoplastic AgentsAntioxidantsDimethyl FumarateGIT 27NO compoundHydrogen PeroxideNitric OxideOxadiazolesProtective AgentsHepG2 cellshydrogen peroxideimmune-inflammationischemia/reperfusion injurynitric oxide

Identifiers

PMID31298048
PMCPMC6628530
OpenAlexW2960987912

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.