Evidence map›Paper›PMID 31297715›Full record

ArticleSleep & breathing = Schlaf & Atmung2020

Intra-night variation in apnea-hypopnea index affects diagnostics and prognostics of obstructive sleep apnea.

Sami Nikkonen, Juha Töyräs, Esa Mervaala, Sami Myllymaa, Philip Terrill, Timo Leppänen

Abstract read
In one paragraph

Article in Sleep & breathing = Schlaf & Atmung, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sami NikkonenDepartment of Applied Physics, University of Eastern Finland, Kuopio, Finland. sami.nikkonen@kuh.fi.ORCID http://orcid.org/0000-0003-0615-4118
Juha TöyräsDepartment of Applied Physics, University of Eastern Finland, Kuopio, Finland.
Esa MervaalaDepartment of Clinical Neurophysiology, Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland.
Sami MyllymaaDepartment of Applied Physics, University of Eastern Finland, Kuopio, Finland.
Philip TerrillSchool of Information Technology and Electrical Engineering, The University of Queensland, Brisbane, Australia.
Timo LeppänenDepartment of Applied Physics, University of Eastern Finland, Kuopio, Finland.

Funding

Academy of Finland 313697Kuopion Yliopistollinen Sairaala 5041754Kuopion Yliopistollinen Sairaala 5041754,5041755Kuopion Yliopistollinen Sairaala 5041755Kuopion Yliopistollinen Sairaala 5041768National Health and Medical Research Council 1064163
6 · The paper itself

Abstract

backgroundDiagnostics of obstructive sleep apnea (OSA) is based on apnea-hypopnea index (AHI) determined as full-night average of occurred events. We investigate our hypothesis that intra-night variation in the frequency of obstructive events affects diagnostics and prognostics of OSA and should therefore be considered in clinical practice.

methodsPolygraphic recordings of 1989 patients (mean follow-up 18.3 years) with suspected OSA were analyzed. Number and severity of individual obstructive events were calculated hourly for the first 6 h of sleep. OSA severity was determined based on the full-night AHI and AHI for the 2 h when the obstructive event frequency was highest (AHI

resultsFrequency and duration of obstructive events varied hour-by-hour increasing towards morning. Using AHI

conclusionsCurrently, the intra-night variation in frequency and severity of obstructive events is completely ignored by conventional, full-night AHI and considering this information could improve the diagnostics of OSA.

Indexed as

PolysomnographyAdultAgedCause of DeathCircadian RhythmDiagnosis, DifferentialFemaleFollow-Up StudiesHumansKaplan-Meier EstimateMaleMiddle AgedPrognosisProportional Hazards ModelsReproducibility of ResultsRisk FactorsAHIDiagnosticsOSAPrognostics

Identifiers

PMID31297715
PMCPMC7127992

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.