Evidence map›Paper›PMID 31297706›Full record

ArticleMolecular imaging and biology2020

Quantitative Assessment of Age-Associated Alterations in Brain Vasculature in Wild-Type Mice and in Bigenic Mice that Model Alzheimer's Disease.

Kristof Govaerts, Tom Dresselaers, Fred Van Leuven, Uwe Himmelreich

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Molecular imaging and biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kristof GovaertsBiomedical MRI/ MoSAIC, Department of Imaging & Pathology, KU Leuven, Herestraat 49, Bus 505, 3000, Leuven, Belgium.
Tom DresselaersBiomedical MRI/ MoSAIC, Department of Imaging & Pathology, KU Leuven, Herestraat 49, Bus 505, 3000, Leuven, Belgium.
Fred Van LeuvenLEGTEGG, Department of Human Genetics, KU Leuven, Leuven, Belgium.
Uwe HimmelreichBiomedical MRI/ MoSAIC, Department of Imaging & Pathology, KU Leuven, Herestraat 49, Bus 505, 3000, Leuven, Belgium. uwe.himmelreich@kuleuven.be.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeVascular dysfunction is a major hallmark of Alzheimer's disease (AD). However, studies that investigated vascular dysfunction in mice modeling AD using magnetic resonance angiography (MRA) are typically limited to qualitative and/or scoring-based paradigms, which are labor-intensive and observer-dependent. PROCEDURES: We developed and validated a semi-automatic MRA processing pipeline and applied this to high-resolution in vivo MRA images acquired on a 9.4T small animal MRI scanner. We assessed vascular morphology at 3, 6, and 12 months in wild-type (WT) and bigenic (APP.V717IxTau.P301L: biAT) mice.

resultsVessel radius or length can increase with age regardless of genotype depending on the respective vessel. We also observed significantly lower internal carotid artery length in biAT mice compared to WT.

conclusionsThe results demonstrate that even subtle changes in vessel morphology can be noninvasively quantified. This is of great interest for AD, but also to other models of neurodegenerative diseases involving macrovascular dysfunction.

Indexed as

Age FactorsAlzheimer DiseaseAnimalsBrainCerebrovascular CirculationDisease Models, AnimalEvaluation Studies as TopicImage Processing, Computer-AssistedMagnetic Resonance AngiographyMagnetic Resonance ImagingMaleMiceMice, TransgenicAgingAlzheimer’s diseaseMagnetic resonance angiographyMorphometryNeurovasculatureSegmentation

Identifiers

PMID31297706

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.