Evidence map›Paper›PMID 31297618›Full record

ArticleAMB Express2019

Antibacterial evaluation of plants extracts against ampicillin-resistant Escherichia coli (E. coli) by microcalorimetry and principal component analysis.

Zhuo Xu, Haotian Li, Xuhua Qin, Tao Wang, Junjie Hao, Jianwei Zhao, Jiabo Wang, Ruilin Wang, Dan Wang, Shizhang Wei and 2 more

Abstract read
In one paragraph

Article in AMB Express, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Wound Healing Effects ofEvidence-based complementary and alternative medicine : eCAM · 2022
    Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zhuo XuCollege of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.
Haotian LiDepartment of Pharmacy, Fifth Medical Center, General Hospital of Chinese PLA, Beijing, 100039, China.
Xuhua QinCollege of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China. 1798941251@qq.com.
Tao WangCollege of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.
Junjie HaoCollege of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.
Jianwei ZhaoChina Astronaut Research and Training Center, Beijing, 100094, China.
Jiabo WangChina Military Institute of Chinese Medicine, Fifth Medical Center, General Hospital of Chinese PLA, Beijing, 100039, China.
Ruilin WangIntegrative Medical Center, Fifth Medical Center, General Hospital of Chinese PLA, Beijing, 100039, China.
Dan WangCollege of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.
Shizhang WeiDepartment of Pharmacy, Fifth Medical Center, General Hospital of Chinese PLA, Beijing, 100039, China.
Huadan CaiDepartment of Pharmacy, Fifth Medical Center, General Hospital of Chinese PLA, Beijing, 100039, China.
Yanling ZhaoDepartment of Pharmacy, Fifth Medical Center, General Hospital of Chinese PLA, Beijing, 100039, China. zhaoyl285528555@126.com.

Funding

the National Major Drug Discovery Project of China 2015ZX09J15102-004
6 · The paper itself

Abstract

Antibiotics abuse has caused increased bacterial resistance, which severely limits the application of antibiotics to the treatment of bacterial infections. Therefore, it is urgent to develop new antibacterial drugs through other sources. Dracontomelon dao (Blanco) Merr. & Rolfe (Ren Mianzi in Chinese) is a traditional medicinal material derived from Anacardiaceae with a long history of treating various infectious diseases, such as decubitus and skin ulcers. Recent research has indicated that different extracts from the leaves of D. dao, especially the ethyl acetate (EtOAc) fraction containing flavonoids and phenolic acids, exhibit potent antibacterial activities. In this research, the combined anti-drug-resistant bacterial activities of these active ingredients were investigated. Six samples (S1-S6) were obtained from the EtOAc fraction of D. dao leaves. Microcalorimetric measurements and principal component analysis were performed on the in vitro samples. The results showed that all six samples had notable antibacterial activities. Specifically, sample S6 exhibited a prominent antibacterial effect, with an IC

Indexed as

Dracontomelon daoDrug-resistant-E. coliMicrocalorimetryPrincipal component analysis

Identifiers

PMID31297618
PMCPMC6624225

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.