Trial reportWorld journal of surgery2019
Comparison of Topical, Systemic, and Combined Therapy with Steroids on Idiopathic Granulomatous Mastitis: A Prospective Randomized Study.
Trial report in World journal of surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Treatment modalities for granulomatous mastitis, seeking the most appropriate treatment with the least recurrence rate: a systematic review and meta-analysis.European journal of medical research · 2024Pooled it
- A meta-analysis of idiopathic granulomatous mastitis treatments for remission and recurrence prevention.Frontiers in medicine · 2024Pooled it
- Factors Affecting Recurrence of Idiopathic Granulomatous Mastitis: A Systematic Review.The breast journal · 2023Pooled it
- Lesion Diameter Versus Inflammatory Biomarkers and Clinical Severity in Predicting Treatment Selection in Idiopathic Granulomatous Mastitis.World journal of surgery · 2026Article
- An endocrine microbe immunity framework for granulomatous mastitis toward phenotype-oriented interpretation.iScience · 2026Review
- Idiopathic granulomatous mastitis: A scoping review to determine the quality and geography of the evidence base.Breast (Edinburgh, Scotland) · 2026Article
- Development and Internal Validation of a Clinical Data-Based Machine Learning Web Calculator for Predicting Recurrence in Granulomatous Lobular Mastitis: A Multicenter Retrospective Study.European journal of breast health · 2026Article
- Idiopathic Granulomatous Mastitis: A Comprehensive Review of Etiology, Diagnosis, and Management.European journal of breast health · 2026Article
- Idiopathic granulomatous mastitis: A narrative review based on the Turkish consensus classification.Turkish journal of surgery · 2026Article
- Granulomatous mastitis: from localized inflammation to systemic immune-mediated disorder.Frontiers in medicine · 2026Review
- The paradoxical effect of oral prednisone in granulomatous lobular mastitis: An observational cohort study.PloS one · 2026Observational
- Evaluating the efficacy of topical steroids in idiopathic granulomatous mastitis: a prospective cohort study.Gland surgery · 2025Article
- Idiopathic Granulomatous Mastitis: A Consensus Report on Treatment and Follow-Up Approaches Based on the Turkish Clinical Classification.Breast care (Basel, Switzerland) · 2025Article
- Idiopathic Granulomatous Mastitis: Immune-Pathogen Imbalance in a Treatment-Resistant Benign Inflammatory Disease.International journal of women's health · 2025Review
- Article
- Comparing the Efficacy of Intralesional Injection versus Systemic Steroids in Treating Idiopathic Granulomatous Mastitis: Insights from a Single-Center Experience.Breast care (Basel, Switzerland) · 2024Article
- Imiquimod as a new treatment in refractory idiopathic granulomatous mastitis: report of two cases.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2024Article
- Staged operation in the surgical treatment of granulomatous lobular mastitis.Gland surgery · 2024Article
- Treatment of Granulomatous Mastitis With Steroids: Should the Decision to End the Treatment be Made Radiologically?European journal of breast health · 2024Article
- Idiopathic Granulomatous Mastitis.The breast journal · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIdiopathic granulomatous mastitis (IGM) is a benign disorder of the breast, for which the optimal treatment modality remains missing.
methodsA total of 124 patients with a histopathologically proven diagnosis of IGM were enrolled in a prospective, randomized parallel arm study. Patients were treated with topical steroids in Group T (n: 42), systemic steroids (0.8 mg/kg/day peroral) in Group S (n: 42), and combined steroids (0.4 mg/kg/day peroral + topical) in Group C (n: 40). Compliance with the therapy, response to the therapy, the duration of therapy, side effects and the recurrence rates were compared.
resultsSixteen patients did not comply with the treatment, and the highest ratio of compliance with therapy was seen in Group T (p < 0.05). Complete clinical regression (CCR) was observed in 90 (83.3%) patients. Response to the treatment (RT) was evaluated radiologically and observed in 89.8% of the patients. There was no statistically significant difference between groups regarding CCR, RT and the recurrence rate. The longest duration of therapy was observed in Group T (22 ± 9.1-week), whereas the shortest was observed in Group S (11.7 ± 5.5-week) (p < 0.001). The systemic side effects were significantly lower in Group T in comparison with Groups S and C (2.4% vs. 38.2% and 30.3%, respectively) (p < 0.001).
conclusionsThe efficiency of the treatment was similar for all groups, both clinically and radiologically. Although the duration of therapy was longer in Group T, the lack of systemic side effects increased the compliance of the patients with the therapy. Therefore, topical steroids would be among first-line treatment options of IGM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.