Evidence map›Paper›PMID 31297461›Full record

ArticleHeliyon2019

Sickling-preventive effects of rutin is associated with modulation of deoxygenated haemoglobin, 2,3-bisphosphoglycerate mutase, redox status and alteration of functional chemistry in sickle erythrocytes.

Aliyu Muhammad, Aliyu Dahiru Waziri, Gilead Ebiegberi Forcados, Babangida Sanusi, Hadiza Sani, Ibrahim Malami, Ibrahim Babangida Abubakar, Habeebah Yahya Oluwatoyin, Otaru Abdulrasheed Adinoyi, Hafsat Abdullahi Mohammed

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 20 citations in OpenAlex.

  1. Phytochemical Characterization ofMolecules (Basel, Switzerland) · 2025
    Article
  2. Article
  3. Article
  4. Natural Antioxidants in Anemia Treatment.International journal of molecular sciences · 2021
    Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Aliyu MuhammadDepartment of Biochemistry, Faculty of Life Sciences, Ahmadu Bello University, Zaria, Kaduna State, Nigeria.
Aliyu Dahiru WaziriDepartment of Haematology, Ahmadu Bello University Teaching Hospital, Zaria, Kaduna State, Nigeria.
Gilead Ebiegberi ForcadosDepartment of Biochemistry, Faculty of Life Sciences, Ahmadu Bello University, Zaria, Kaduna State, Nigeria.
Babangida SanusiDepartment of Biochemistry, Faculty of Life Sciences, Ahmadu Bello University, Zaria, Kaduna State, Nigeria.
Hadiza SaniDepartment of Medicine, Kaduna State University, Kaduna State, Nigeria.
Ibrahim MalamiDepartment of Pharmacognosy and Ethnopharmacy, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, PMB 2346, Sokoto, Nigeria.
Ibrahim Babangida AbubakarDepartment of Biochemistry, Faculty of Life Sciences, Kebbi State University of Science and Technology, Aliero, PMB 1144, Kebbi State, Nigeria.
Habeebah Yahya OluwatoyinDepartment of Biochemistry, Faculty of Life Sciences, Ahmadu Bello University, Zaria, Kaduna State, Nigeria.
Otaru Abdulrasheed AdinoyiDepartment of Biochemistry, Faculty of Life Sciences, Ahmadu Bello University, Zaria, Kaduna State, Nigeria.
Hafsat Abdullahi MohammedDepartment of Biochemistry, Faculty of Life Sciences, Ahmadu Bello University, Zaria, Kaduna State, Nigeria.
Ahmadu Bello University · NGAhmadu Bello University Teaching Hospital · NGKaduna State University · NGKebbi State University of Science and Technology · NGUsmanu Danfodiyo University · NG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sickle cell anaemia is a hereditary disease branded by an upsurge in generation of ROS, irregular iron release and little or no antioxidant activity which can lead to cellular injuries due to oxidative stress resulting in severe symptoms including anaemia and pain. The disease is caused by a mutated version of the gene that helps make haemoglobin, the protein that carries oxygen in red blood cells. We used

Indexed as

AntisicklingCell biologyErythrocytesHaemoglobinRedoxRutin

Identifiers

PMID31297461
PMCPMC6597891
OpenAlexW2954652511

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.