ArticleFrontiers in physiology2019
Variable Ventilation Is Equally Effective as Conventional Pressure Control Ventilation for Optimizing Lung Function in a Rabbit Model of ARDS.
Article in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 23 citations in OpenAlex.
- Article
- Lung recruitment by continuous negative extra-thoracic pressure support following one-lung ventilation: an experimental study.Frontiers in physiology · 2023Article
- Expiratory high-frequency percussive ventilation: a novel concept for improving gas exchange.Respiratory research · 2022Article
- Flow-controlled ventilation maintains gas exchange and lung aeration in a pediatric model of healthy and injured lungs: A randomized cross-over experimental study.Frontiers in pediatrics · 2022Article
- Mining the key genes for ventilator-induced lung injury using co-expression network analysis.Bioscience reports · 2021Article
- Physiologically variable ventilation reduces regional lung inflammation in a pediatric model of acute respiratory distress syndrome.Respiratory research · 2020Article
- Sigh maneuver protects healthy lungs during mechanical ventilation in adult Wistar rats.Experimental biology and medicine (Maywood, N.J.) · 2020Article
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Authors and funding
8 authors at 2 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntroducing mathematically derived variability (MVV) into the otherwise monotonous conventional mechanical ventilation has been suggested to improve lung recruitment and gas exchange. Although the application of a ventilation pattern based on variations in physiological breathing (PVV) is beneficial for healthy lungs, its value in the presence of acute respiratory distress syndrome (ARDS) has not been characterized. We therefore aimed at comparing conventional pressure-controlled ventilation with (PCS) or without regular sighs (PCV) to MVV and PVV at two levels of positive end-expiratory pressure (PEEP) in a model of severe ARDS.
methodsAnesthetised rabbits (
resultsAlthough no progression of lung injury was observed after 5 h of ventilation at PEEP 6 cmH
conclusionAt moderate PEEP, variable ventilation based on a pre-recorded physiological breathing pattern protected against progression of lung injury equally to the conventional pressure-controlled mode, whereas mathematical variability or application of regular sighs caused worsening in lung mechanics. This outcome may be related to the excessive increases in peak inspiratory pressure with the latter ventilation modes. However, a greater benefit on respiratory mechanics and gas exchange could be obtained by elevating PEEP, compared to the ventilation mode in severe ARDS.
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