Evidence map›Paper›PMID 31297038›Full record

ArticleThrombosis journal2019

Usefulness of the APTT waveform for the diagnosis of DIC and prediction of the outcome or bleeding risk.

Kei Suzuki, Hideo Wada, Takeshi Matsumoto, Makoto Ikejiri, Kohshi Ohishi, Yoshiki Yamashita, Hiroshi Imai, Toshiaki Iba, Naoyuki Katayama

Open access · goldAbstract read
In one paragraph

Article in Thrombosis journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 36 citations in OpenAlex.

  1. A comparison of anti-coagulation monitoring tests in ICU patients receiving a continuous infusion of unfractionated heparin.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2024
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  13. The Evaluation of Hemostatic Abnormalities Using a CWA-Small Amount Tissue Factor Induced FIX Activation Assay in Major Orthopedic Surgery Patients.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Article
  14. The First-Derivative Curve of the Coagulation Waveform Reveals the Cause of aPTT Prolongation.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Article
  15. Update on the Clot Waveform Analysis.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Article
  16. Clinical Application of Clot Waveform Analysis.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Kei Suzuki1Emergency Critical Care Center, Mie University Graduate School of Medicine, Tsu, Mie Japan.
Hideo Wada2Departments of Molecular and Laboratory Medicine, Mie University Graduate School of Medicine, Tsu, Mie 514-8507 Japan.ORCID 0000-0001-9021-8633
Takeshi Matsumoto3Division of Blood Transfusion Medicine and Cell Therapy, Mie University Graduate School of Medicine, Tsu, Mie Japan.
Makoto Ikejiri4Central laboratory, Mie University Graduate School of Medicine, Tsu, Mie Japan.
Kohshi Ohishi3Division of Blood Transfusion Medicine and Cell Therapy, Mie University Graduate School of Medicine, Tsu, Mie Japan.
Yoshiki Yamashita5Department of Hematology and Oncology, Mie University Graduate School of Medicine, Tsu, Mie Japan.
Hiroshi Imai1Emergency Critical Care Center, Mie University Graduate School of Medicine, Tsu, Mie Japan.
Toshiaki Iba6Department of Emergency and Disaster Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Naoyuki Katayama5Department of Hematology and Oncology, Mie University Graduate School of Medicine, Tsu, Mie Japan.
Mie University · JPJuntendo University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe usefulness of the activated partial thromboplastin time (APTT) waveform has been reported in hemophilia, acquired hemophilia and monitoring for anticoagulants. MATERIAL AND

methodsThe APTT waveform was examined in patients suspected of having disseminated intravascular coagulation (DIC) to analyze its usefulness for the diagnosis of DIC or the prediction of the outcome or bleeding risk.

resultsDIC with fibrinogen < 2 g/L was frequently associated with infectious diseases (43.3%). The heights of the first derivative peak (1stDP) and second DP (2ndDP) were extremely low in DIC, especially DIC with hypofibrinogenemia, but high in infectious patients without DIC. The peak time and width of the 1stDP and 2ndDP were prolonged in patients with DIC. The heights of the 1 DISCUSSION AND

conclusionAs bleeding type DIC was observed in infectious DIC, DIC without hypofibrinogenemia might switch to DIC with hypofibrinogenemia by the progression of DIC. The height of the 1

Indexed as

APTT waveformBleedingHypofibrinogenemiaOutcome

Identifiers

PMID31297038
PMCPMC6598339
OpenAlexW2954965037

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.