Evidence map›Paper›PMID 31296969›Full record

ReviewNature reviews. Gastroenterology & hepatology2019

Probiotics and prebiotics in intestinal health and disease: from biology to the clinic.

Mary Ellen Sanders, Daniel J Merenstein, Gregor Reid, Glenn R Gibson, Robert A Rastall

Erratum issuedAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Gastroenterology & hepatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 935 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
935citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

935 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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875 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Mary Ellen SandersInternational Scientific Association for Probiotics and Prebiotics, Centennial, CO, USA.
Daniel J MerensteinDepartment of Family Medicine, Georgetown University Medical Center, Washington, DC, USA.
Gregor ReidLawson Research Institute, and Western University, London, Ontario, Canada.ORCID http://orcid.org/0000-0001-9658-5696
Glenn R GibsonDepartment of Food and Nutritional Sciences, University of Reading, Reading, UK. g.r.gibson@reading.ac.uk.ORCID http://orcid.org/0000-0002-0566-0476
Robert A RastallDepartment of Food and Nutritional Sciences, University of Reading, Reading, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Probiotics and prebiotics are microbiota-management tools for improving host health. They target gastrointestinal effects via the gut, although direct application to other sites such as the oral cavity, vaginal tract and skin is being explored. Here, we describe gut-derived effects in humans. In the past decade, research on the gut microbiome has rapidly accumulated and has been accompanied by increased interest in probiotics and prebiotics as a means to modulate the gut microbiota. Given the importance of these approaches for public health, it is timely to reiterate factual and supporting information on their clinical application and use. In this Review, we discuss scientific evidence on probiotics and prebiotics, including mechanistic insights into health effects. Strains of Lactobacillus, Bifidobacterium and Saccharomyces have a long history of safe and effective use as probiotics, but Roseburia spp., Akkermansia spp., Propionibacterium spp. and Faecalibacterium spp. show promise for the future. For prebiotics, glucans and fructans are well proven, and evidence is building on the prebiotic effects of other substances (for example, oligomers of mannose, glucose, xylose, pectin, starches, human milk and polyphenols).

Indexed as

PrebioticsProbioticsGastrointestinal DiseasesGastrointestinal MicrobiomeHumansPrebiotics

Identifiers

PMID31296969

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.