ReviewNature reviews. Gastroenterology & hepatology2019
First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques.
Review in Nature reviews. Gastroenterology & hepatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed, 3 syntheses or guidelines pooled it, 143 citations in OpenAlex.
- The Clinical Relevance of the Rectosigmoid Brake in Surgical Disorders and Therapies: A Systematic Review of Colonic Manometry Studies.Neurogastroenterology and motility · 2026Pooled it
- Thirty years of paediatric colonic motility assessment modalities: a systematic review.Frontiers in pediatrics · 2026Pooled it
- Post-operative colonic manometry in children with anorectal malformations: A systematic review.Neurogastroenterology and motility · 2022Pooled it
- Dup15q model mice exhibit impaired gastrointestinal motility and a constipation-like phenotype, alleviated by prucalopride.Translational psychiatry · 2026Article
- Optimizing blue poo: A validated, cost-effective method for measuring whole gut transit time.MethodsX · 2026Article
- A Biophysical Model of Human Colonic Motor Pattern Generation in Health and Disease.bioRxiv : the preprint server for biology · 2026Article
- Ultrasound assessment of constipation: do not put the cart before the horse.Internal and emergency medicine · 2026Article
- Miniature endoscope for high resolution electrophysiological recordings from the colon of live mice.Nature communications · 2026Article
- Coordinated regulation of colonic fluid and mucus secretion.Frontiers in pharmacology · 2026Review
- Unique properties of proximal and distal colon reflect distinct motor functions.American journal of physiology. Gastrointestinal and liver physiology · 2025Review
- Ca²⁺ signaling in myenteric interstitial cells of Cajal (ICC-MY) and their role as conditional pacemakers in the colon.Cell calcium · 2025Article
- Effect of propinox and pinaverium bromide onFrontiers in pharmacology · 2025Article
- BAP1 is required prenatally for differentiation and maintenance of postnatal murine enteric nervous system.The Journal of clinical investigation · 2024Article
- Validation of body surface colonic mapping (BSCM) against high resolution colonic manometry for evaluation of colonic motility.Scientific reports · 2024Article
- Novel insights into mechanisms of inhibition of colonic motility by loperamide.Frontiers in neuroscience · 2024Article
- CaPhysiological reviews · 2024Review
- Evaluation of the mechanism of action of paracetamol, drotaverine, and peppermint oil and their effects in combination with hyoscine butylbromide on colonic motility: humanFrontiers in pharmacology · 2024Article
- Review
- Functional and Transcriptomic Characterization of Postnatal Maturation of ENS and SIP Syncytium in Mice Colon.Biomolecules · 2023Article
- An Optogenetics-based Approach to Regulate Colonic Contractions by Modulating the Activity of the Interstitial Cells of Cajal in Mice.Journal of neurogastroenterology and motility · 2023Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 13 institutions in 9 countries.
Funding
Abstract
Alterations in colonic motility are implicated in the pathophysiology of bowel disorders, but high-resolution manometry of human colonic motor function has revealed that our knowledge of normal motor patterns is limited. Furthermore, various terminologies and definitions have been used to describe colonic motor patterns in children, adults and animals. An example is the distinction between the high-amplitude propagating contractions in humans and giant contractions in animals. Harmonized terminology and definitions are required that are applicable to the study of colonic motility performed by basic scientists and clinicians, as well as adult and paediatric gastroenterologists. As clinical studies increasingly require adequate animal models to develop and test new therapies, there is a need for rational use of terminology to describe those motor patterns that are equivalent between animals and humans. This Consensus Statement provides the first harmonized interpretation of commonly used terminology to describe colonic motor function and delineates possible similarities between motor patterns observed in animal models and humans in vitro (ex vivo) and in vivo. The consolidated terminology can be an impetus for new research that will considerably improve our understanding of colonic motor function and will facilitate the development and testing of new therapies for colonic motility disorders.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.